The character of a cell is defined by its constituent proteins, which are the result of specific
patterns of gene expression. Crucial determinants of gene expression patterns are DNA …

Genomic imprinting affects several dozen mammalian genes and results in the expression of
those genes from only one of the two parental chromosomes. This is brought about by …

In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of
many cytosine residues to 5-methylcytosine. For several years, control of gene activity by …

The chromosomal region, 15q11-q13, involved in Prader-Willi and Angelman syndromes
(PWS and AS) represents a paradigm for understanding the relationships between genome …

Fundamental to genomic imprinting in mammals is the acquisition of epigenetic marks that
differ in male and female gametes at 'imprinting control regions'(ICRs). These marks mediate …

Prader–Willi syndrome (PWS) and Angelman syndrome (AS) are two distinct
neurodevelopmental disorders, each caused by several genetic and epigenetic …

Genomic imprinting confers a developmental asymmetry on the parental genomes, through
epigenetic modifications in the germ line and embryo. These heritable modifications …

A human imprinted domain at 14q32 contains two co-expressed and reciprocally imprinted
genes, DLK1 and GTL2, which are expressed from the paternally and maternally inherited …

▪ Abstract Eukaryotic genomes are distributed on linear chromosomes that are grouped
together in the nucleus, an organelle separated from the cytoplasm by a characteristic …

Pediatric germ cell tumors (GCTs) commonly arise at extragonadal sites. It has been
proposed that nongonadal GCTs arise from ectopic primordial germ cells that have …