Valvular heart disease is a major cause of morbidity and mortality worldwide. Surgical valve
repair or replacement has been the standard of care for patients with valvular heart disease …

Precision medicine is a new frontier in healthcare that uses scientific methods to customize
medical treatment to the individual genes, anatomy, physiology, and lifestyle of each person …

Valvular heart disease is an important source of cardiovascular morbidity and mortality.
Current prosthetic valve replacement options, such as bioprosthetic and mechanical heart …

The native human heart valve leaflet contains a layered microstructure comprising a
hierarchical arrangement of collagen, elastin, proteoglycans and various cell types. Here …

Background The postoperative outcomes of transcatheter aortic valve replacement (TAVR)
with the new generation of self-expanding valves (SEV) and balloon-expandable valves …

Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure that
provides an effective alternative to open-heart surgical valve replacement for treating …

Aortic stenosis (AS) is the most prevalent heart valve disease in western countries that
poses a significant public health challenge due to the lack of a medical treatment to prevent …

Nearly a century after rheumatic fever (RF) and rheumatic heart disease (RHD) was
eradicated from the developed world, the disease remains endemic in many low-and middle …

Self-expandable transcatheter aortic valves (TAVs) elastically resume their initial shape
when implanted without the need for balloon inflation by virtue of the nickel–titanium (NiTi) …

The complicated interaction between a fluid flow and a deformable structure is referred to as
fluid–structure interaction (FSI). FSI plays a crucial role in the functioning of the aortic valve …