All life forms have evolved under the constant force of gravity on Earth and developed ways
to counterbalance acceleration load. In space, shear forces, buoyance-driven convection …

Functioning as the outermost self-renewing protective layer of the human organism, skin
protects against a multitude of harmful biological and physical stimuli. Consisting of …

Spaceflight-associated immune system weakening ultimately limits the ability of humans to
expand their presence beyond the earth's orbit. A mechanistic study of microgravity …

We have identified and validated a spaceflight-associated microRNA (miRNA) signature that
is shared by rodents and humans in response to simulated, short-duration and long-duration …

Novel, non-invasive biomarkers to diagnose breast cancer with high sensitivity and
specificity are greatly desired. Circulating microRNAs (miRNAs) show potential for breast …

Gravity constituted the only constant environmental parameter, during the evolutionary
period of living matter on Earth. However, whether gravity has affected the evolution of …

In the era of renewed space exploration, comprehending the effects of the space
environment on human health, particularly for deep space missions, is crucial. While …

Abstract microRNAs (miRNAs) post-transcriptionally regulate the expression of targeted
genes. We here systematically identify miRNAs in response to simulated microgravity based …

Abundant evidence demonstrates that mechanical stress could induce an inflammatory
response in periodontal tissue, but the precise mechanism remains unclear. In the past few …

Translating fundamental biological discoveries from NASA Space Biology program into
health risk from space flights has been an ongoing challenge. We propose to use NASA …