Urticaria is an inflammatory skin disorder that affects up to 20% of the world population at
some point during their life. It presents with wheals, angioedema or both due to activation …

Mast cells have crucial roles in allergic and other inflammatory diseases. Preclinical
approaches provide circumstantial evidence for mast cell involvement in many diseases, but …

Antecedentes Esta la segunda actualización de una revisión publicada anteriormente en la
Biblioteca Cochrane (2015, primera actualización en 2017). La interleucina 5 (IL‐5) es la …

Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

Chronic spontaneous urticaria is characterized by a perivascular non-necrotizing cellular
infiltrate around small venules of the skin. It consists primarily of CD4 (+) lymphocytes, a …

The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …

Background Chronic urticaria (CU) is a debilitating mast cell–driven disease, often refractory
to standard therapy (ie, antihistamines). Lirentelimab, an anti–sialic acid–binding …

Background In eosinophilic gastrointestinal diseases, the role of eosinophils in disease
pathogenesis and the effect of eosinophil depletion on patient outcomes are unclear …

Chronic urticaria (CU) is a common skin condition characterized by the recurrence of
wheals, with or without angioedema, which lasts for at least 6 weeks. Owing to its pruritus …

Chronic urticaria is a common and debilitating mast cell-driven skin disease presenting with
itchy wheals, angio-oedema, or both. Chronic urticaria is classified as spontaneous (without …