Antioxidant Activity of Leaf Extracts from Stevia rebaudiana Bertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis

M Papaefthimiou, PI Kontou, PG Bagos, GG Braliou - Nutrients, 2023 - mdpi.com
Stevia (Stevia rebaudiana Bertoni) is an aromatic plant known for its high sweetening power
ascribed to its glycosides. Stevia also contains several bioactive compounds showing …

[HTML][HTML] Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: therapeutic targeting, challenges and future prospective

M Hashemi, MA Zandieh, S Ziaolhagh… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …

Exercise augments the effect of SGLT2 inhibitor dapagliflozin on experimentally induced diabetic cardiomyopathy, possible underlying mechanisms

M Eldesoqui, ZH Eldken, SA Mostafa, RH Al-Serwi… - Metabolites, 2022 - mdpi.com
One of the most prevalent cardiovascular problems linked with type 2 diabetes mellitus
(T2DM) is diabetic cardiomyopathy (DCM). DCM is associated with myocardial oxidative …

[HTML][HTML] Effects of Stevia rebaudiana Bertoni extracts in the rat model of epilepsy induced by pentylenetetrazol: Sirt-1, at the crossroads between inflammation and …

EM El Nashar, W Obydah, MA Alghamdi… - Journal of Integrative …, 2022 - imrpress.com
The current study investigated the effects of stevia extracts on a PTZ-induced epileptic rat
model and its potential mechanism. Thirty male Sprague-Dawley rats were equally …

Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling

W Zhang, Y Dun, B You, L Qiu… - BMJ Open Diabetes …, 2022 - drc.bmj.com
Introduction Insulin resistance (IR) plays a key role in the pathogenesis and clinical course
of patients with multiple metabolic diseases and diabetes. This study aimed to explore the …

Cardiac innervations in diabetes mellitus—Anatomical evidence of neuropathy

N Filipović, M Marinović Guić, V Košta… - The Anatomical …, 2023 - Wiley Online Library
The extensive innervations of the heart include a complex network of sympathetic,
parasympathetic, and sensory nerves connected in loops that serve to regulate cardiac …

[HTML][HTML] Structure, Properties, and Biomedical Activity of Natural Sweeteners Steviosides: An Update

A Wang, H Hu, Y Yuan, S Mei, G Zhu… - Food Science & …, 2025 - pmc.ncbi.nlm.nih.gov
Stevioside is a natural sweetener with the characteristics of low calorie and high sweetness.
It comprises a diverse range of monomers that play crucial roles in numerous biological …

[PDF][PDF] Protective effect of Stevia on diabetic induced testicular damage: an immunohistochemical and ultrastructural study.

M Elshafey, OS Erfan, E Risha… - European Review for …, 2023 - researchgate.net
OBJECTIVE: Diabetes mellitus (DM) has been considered a major problem because of its
related complications and growing incidence worldwide. Testicular dysfunction has become …

[HTML][HTML] The possible effects of the aqueous extract of Stevia Rebaudiana on autophagic clearance and sympathetic nerve density in pancreatic β cells of type 2 …

ZH Eldken, SM Safwat, NH Sakr, EM El Nashar… - Journal of Functional …, 2023 - Elsevier
Background Diabetes mellitus (DM) is a common metabolic disorder affecting more than 400
million people worldwide. Pancreatic islet cell failure due to partial loss or dysfunction of islet …

Bioactivities and biotechnological tools for obtaining bioactive metabolites from Stevia rebaudiana

TFO da Silva, AA Ferrarezi, É da Silva Santos… - Food Science and …, 2025 - Springer
Several natural compounds have already been isolated from the leaves of the Stevia
rebaudiana, the main ones are stevioside and rebaudiosides, which are used commercially …