Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely
investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence …

There is a growing trend towards exploring the use of a minimally invasive “liquid biopsy” to
identify biomarkers in a number of cancers, including urologic malignancies. Multiple …

The effective and efficient management of cancer patients relies upon early diagnosis and/or
the monitoring of treatment, something that is often difficult to achieve using standard tissue …

Background Growing evidence is showing that metastatic cell populations are able to
transfer their characteristics to less malignant cells. Exosomes (EXOs) are membrane …

Tumor heterogeneity is a major challenge and the root cause of resistance to treatment. Still,
the standard diagnostic approach relies on the analysis of a single tumor sample from a …

A class of small non-coding RNAs, the microRNAs (miRNAs), have recently attracted great
attention in cancer research since they play a central role in regulation of gene-expression …

In-depth insights in cancer biology over the past decades have highlighted the important
roles of epigenetic mechanisms in the initiation and progression of tumorigenesis. The …

MicroRNAs (miRNAs) are secreted by cells in vesicles, bound in a ribonucleoprotein
complex or as free molecules. These miRNA secretion pathways are dysregulated in cancer …

Circulating microRNAs (miRNAs) are emerging as clinically useful tools for cancer detection;
however, little is known about their early diagnostic impact on RCC. The levels of 754 serum …

A thorough understanding of the tumor environment and underlying genetic factors helps in
the better formulation of cancer management strategies. Availability of efficient diagnostic …