The chemistry of snake venom and its medicinal potential

AL Oliveira, MF Viegas, SL da Silva… - Nature Reviews …, 2022 - nature.com
The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

[HTML][HTML] Snake venoms in drug discovery: valuable therapeutic tools for life saving

T Mohamed Abd El-Aziz, AG Soares, JD Stockand - Toxins, 2019 - mdpi.com
Animal venoms are used as defense mechanisms or to immobilize and digest prey. In fact,
venoms are complex mixtures of enzymatic and non-enzymatic components with specific …

Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: A comprehensive review

B Lomonte - Toxicon, 2023 - Elsevier
Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

[HTML][HTML] Antimicrobials from venomous animals: An overview

T Yacoub, M Rima, M Karam, JM Sabatier, Z Fajloun - Molecules, 2020 - mdpi.com
The inappropriate or excessive use of antimicrobial agents caused an emerging public
health problem due to the resulting resistance developed by microbes. Therefore, there is an …

Snake venom L‐amino acid oxidases: Trends in pharmacology and biochemistry

LFM Izidoro, JC Sobrinho, MM Mendes… - BioMed research …, 2014 - Wiley Online Library
L‐amino acid oxidases are enzymes found in several organisms, including venoms of
snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is …

Neurotoxins acting at synaptic sites: A brief review on mechanisms and clinical applications

K Zhou, W Luo, T Liu, Y Ni, Z Qin - Toxins, 2022 - mdpi.com
Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

Past decade study of snake venom L-amino acid oxidase

C Guo, S Liu, Y Yao, Q Zhang, MZ Sun - Toxicon, 2012 - Elsevier
As one of the major protein (enzyme) components of snake venom (SV), l-amino acid
oxidase (LAAO) plays an important role in the toxicities and biological activities for SV …

Snake venom: From fieldwork to the clinic: Recent insights into snake biology, together with new technology allowing high‐throughput screening of venom, bring new …

FJ Vonk, K Jackson, R Doley, F Madaras… - …, 2011 - Wiley Online Library
Snake venoms are recognized here as a grossly under‐explored resource in
pharmacological prospecting. Discoveries in snake systematics demonstrate that former …

Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation

SC Yadav, A Kumari, R Yadav - Peptides, 2011 - Elsevier
The targeted delivery of therapeutic peptide by nanocarriers systems requires the
knowledge of interactions of nanomaterials with the biological environment, peptide release …

Structure–function studies and mechanism of action of snake venom L-amino acid oxidases

A Ullah - Frontiers in pharmacology, 2020 - frontiersin.org
Snake venom L-amino acid oxidases (SV-LAAOs) are the least studied venom enzymes.
These enzymes catalyze the stereospecific oxidation of an L-amino acid to their …