Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …

According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …

The accumulation of senescent cells is a major cause of age-related inflammation and
predisposes to a variety of age-related diseases. However, little is known about the …

Prostate cancer (PCa) affects millions of men globally. Due to advances in understanding
genomic landscapes and biological functions, the treatment of PCa continues to improve …

Cancer cells rewire metabolism to favour the generation of specialized metabolites that
support tumour growth and reshape the tumour microenvironment,. Lysine functions as a …

Summary Cyclic GMP-AMP synthase (cGAS) is the major sensor for cytosolic DNA and
activates type I interferon signaling and plays an essential role in antitumor immunity …

Conclusions: Our study sheds light on the pivotal role of METTL1 in modulating an
immunosuppressive microenvironment and demonstrated that interrupting METTL1‐TGF‐β2 …

Epigenetic modifications, including posttranslational modifications of histones, are closely
linked to transcriptional regulation. Trimethylated H3 lysine 4 (H3K4me3) is one of the most …

Metastasis is the major cause of cancer-related deaths due to the lack of effective therapies.
Emerging evidence suggests that certain epigenetic and transcriptional regulators drive …

Abstract Programmed death-1 (PD-1) inhibitors are approved for therapy of gynecologic
cancers with DNA mismatch repair deficiency (dMMR), although predictors of response …