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RNA splicing factors as oncoproteins and tumour suppressors
H Dvinge, E Kim, O Abdel-Wahab… - Nature Reviews Cancer, 2016 - nature.com
The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …
Therapeutic targeting of splicing in cancer
Recent studies have highlighted that splicing patterns are frequently altered in cancer and
that mutations in genes encoding spliceosomal proteins, as well as mutations affecting the …
that mutations in genes encoding spliceosomal proteins, as well as mutations affecting the …
[HTML][HTML] Disruptive CHD8 mutations define a subtype of autism early in development
Autism spectrum disorder (ASD) is a heterogeneous disease in which efforts to define
subtypes behaviorally have met with limited success. Hypothesizing that genetically based …
subtypes behaviorally have met with limited success. Hypothesizing that genetically based …
Hypoxia, hypoxia-inducible transcription factors, and renal cancer
Context Renal cancer is a common urologic malignancy, and therapeutic options for
metastatic disease are limited. Most clear cell renal cell carcinomas (ccRCC) are associated …
metastatic disease are limited. Most clear cell renal cell carcinomas (ccRCC) are associated …
Regulation of alternative splicing through coupling with transcription and chromatin structure
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …
genetic information from DNA to proteins by expanding the coding capacity of genomes …
Coupling of RNA polymerase II transcription elongation with pre-mRNA splicing
Pre-mRNA maturation frequently occurs at the same time and place as transcription by RNA
polymerase II. The co-transcriptionality of mRNA processing has permitted the evolution of …
polymerase II. The co-transcriptionality of mRNA processing has permitted the evolution of …
Widespread intron retention diversifies most cancer transcriptomes
Background Somatic mutations affecting components of the RNA splicing machinery occur
with high frequencies across many tumor types. These mutations give rise to distinct …
with high frequencies across many tumor types. These mutations give rise to distinct …
The changing paradigm of intron retention: regulation, ramifications and recipes
Intron retention (IR) is a form of alternative splicing that has long been neglected in
mammalian systems although it has been studied for decades in non-mammalian species …
mammalian systems although it has been studied for decades in non-mammalian species …
Noncoding RNAs regulate alternative splicing in Cancer
Y Liu, X Liu, C Lin, X Jia, H Zhu, J Song… - Journal of Experimental & …, 2021 - Springer
AS (alternative splicing) is a fundamental process by which a gene can generate multiple
distinct mRNA transcripts to increase protein diversity. Defects in AS influence the …
distinct mRNA transcripts to increase protein diversity. Defects in AS influence the …
[HTML][HTML] Nfib promotes metastasis through a widespread increase in chromatin accessibility
Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic
progression remain poorly understood. We isolated pure populations of cancer cells from …
progression remain poorly understood. We isolated pure populations of cancer cells from …