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Cellular distribution and functions of P2 receptor subtypes in different systems
In 1929 Drury and Szent-Györgyi published a seminal paper describing the potent actions of
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …
adenine compounds. Some decades later, adenosine 5'-triphosphate (ATP) was proposed …
Sinonasal mucociliary clearance in health and disease
Although much has been elucidated in the past 170 years concerning the precise
mechanism of ciliary function in the healthy or diseased human respiratory system …
mechanism of ciliary function in the healthy or diseased human respiratory system …
Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide …
Nucleotides are important extracellular signaling molecules. At least five mammalian P2Y
receptors exist that are specifically activated by ATP, UTP, ADP, or UDP. Although the …
receptors exist that are specifically activated by ATP, UTP, ADP, or UDP. Although the …
Control of epithelial transport via luminal P2 receptors
P2 membrane receptors are specifically activated by extracellular nucleotides like ATP,
ADP, UTP, and UDP. P2 receptors are subdivided into metabotropic P2Y and ionotropic P2X …
ADP, UTP, and UDP. P2 receptors are subdivided into metabotropic P2Y and ionotropic P2X …
Purinergic signaling in the airways
Evidence for a significant role and impact of purinergic signaling in normal and diseased
airways is now beyond dispute. The present review intends to provide the current state of …
airways is now beyond dispute. The present review intends to provide the current state of …
Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency
Abstract Objectives/Hypothesis: Although the pathophysiology leading to rhinosinusitis is
complex, evidence indicates that decreased mucociliary clearance (MCC) is a major …
complex, evidence indicates that decreased mucociliary clearance (MCC) is a major …
Cigarette smoke-induced Ca2+ release leads to cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction
JE Rasmussen, JT Sheridan, W Polk, CM Davies… - Journal of Biological …, 2014 - jbc.org
Chronic obstructive pulmonary disease affects 64 million people and is currently the fourth
leading cause of death worldwide. Chronic obstructive pulmonary disease includes both …
leading cause of death worldwide. Chronic obstructive pulmonary disease includes both …
[HTML][HTML] Memantine ameliorates pulmonary inflammation in a mice model of COPD induced by cigarette smoke combined with LPS
Q Cheng, L Fang, D Feng, S Tang, S Yue… - Biomedicine & …, 2019 - Elsevier
An enhanced chronic inflammatory response in the airways has been regarded as a critical
characteristic of chronic obstructive pulmonary disease (COPD). Memantine, an N-methyl-d …
characteristic of chronic obstructive pulmonary disease (COPD). Memantine, an N-methyl-d …
Regulation of ciliary beat frequency by the nitric oxide–cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells
Nitric oxide (NO) upregulates ciliary beat frequency (CBF). The present study evaluates
mechanisms of the NO–cyclic guanosine monophosphate (cGMP) pathway regulation of …
mechanisms of the NO–cyclic guanosine monophosphate (cGMP) pathway regulation of …
Airway hydration and COPD
Chronic obstructive pulmonary disease (COPD) is one of the prevalent causes of worldwide
mortality and encompasses two major clinical phenotypes, ie, chronic bronchitis (CB) and …
mortality and encompasses two major clinical phenotypes, ie, chronic bronchitis (CB) and …