Pathological synchronization in Parkinson's disease: networks, models and treatments
Parkinson's disease is a common and disabling disorder of movement owing to
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …
dopaminergic denervation of the striatum. However, it is still unclear how this denervation …
Understanding the role of sensorimotor beta oscillations
Beta oscillations have been predominantly observed in sensorimotor cortices and basal
ganglia structures and they are thought to be involved in somatosensory processing and …
ganglia structures and they are thought to be involved in somatosensory processing and …
New insights into the relationship between dopamine, beta oscillations and motor function
Synchronised neuronal oscillations at beta frequencies are prevalent in the human motor
system, but their function is unclear. In this Opinion article, we propose that the levels of beta …
system, but their function is unclear. In this Opinion article, we propose that the levels of beta …
Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity
Parkinson's disease (PD) is associated with exaggerated oscillatory synchrony in the basal
ganglia at frequencies over 8–35 Hz. Studies have demonstrated a suppression of local field …
ganglia at frequencies over 8–35 Hz. Studies have demonstrated a suppression of local field …
Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease
M Weinberger, N Mahant… - Journal of …, 2006 - journals.physiology.org
Recent studies suggest that beta (15–30 Hz) oscillatory activity in the subthalamic nucleus
(STN) is dramatically increased in Parkinson's disease (PD) and may interfere with …
(STN) is dramatically increased in Parkinson's disease (PD) and may interfere with …
Oscillations and the basal ganglia: motor control and beyond
Oscillations form a ubiquitous feature of the central nervous system. Evidence is accruing
from cortical and sub-cortical recordings that these rhythms may be functionally important …
from cortical and sub-cortical recordings that these rhythms may be functionally important …
Abnormal oscillatory synchronisation in the motor system leads to impaired movement
P Brown - Current opinion in neurobiology, 2007 - Elsevier
Converging data suggest that abnormal synchronised oscillatory activity in the basal ganglia
may contribute to bradykinesia in patients with Parkinson's disease. This synchrony …
may contribute to bradykinesia in patients with Parkinson's disease. This synchrony …
Coupling between beta and high-frequency activity in the human subthalamic nucleus may be a pathophysiological mechanism in Parkinson's disease
J López-Azcárate, M Tainta… - Journal of …, 2010 - Soc Neuroscience
In Parkinson's disease (PD), the oscillatory activity recorded from the basal ganglia shows
dopamine-dependent changes. In the “off” parkinsonian motor state, there is prominent …
dopamine-dependent changes. In the “off” parkinsonian motor state, there is prominent …
Synchronized neural oscillations and the pathophysiology of Parkinson's disease
Oscillatory activities across multiple frequency bands and their cross-frequency interactions
within spatially segregated loops of the basal ganglia-thalamo-cortical system may relate to …
within spatially segregated loops of the basal ganglia-thalamo-cortical system may relate to …
What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease?
Feedback control of deep brain stimulation (DBS) in Parkinson's disease has great potential
to improve efficacy, reduce side effects, and decrease the cost of treatment. In this, the timing …
to improve efficacy, reduce side effects, and decrease the cost of treatment. In this, the timing …