An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
[HTML][HTML] Protein post-translational modifications: In silico prediction tools and molecular modeling
M Audagnotto, M Dal Peraro - Computational and structural biotechnology …, 2017 - Elsevier
Post-translational modifications (PTMs) occur in almost all proteins and play an important
role in numerous biological processes by significantly affecting proteins' structure and …
role in numerous biological processes by significantly affecting proteins' structure and …
Predicting antimicrobial peptides with improved accuracy by incorporating the compositional, physico-chemical and structural features into Chou's general PseAAC
Antimicrobial peptides (AMPs) are important components of the innate immune system that
have been found to be effective against disease causing pathogens. Identification of AMPs …
have been found to be effective against disease causing pathogens. Identification of AMPs …
iPromoter-2L: a two-layer predictor for identifying promoters and their types by multi-window-based PseKNC
B Liu, F Yang, DS Huang, KC Chou - Bioinformatics, 2018 - academic.oup.com
Motivation Being responsible for initiating transaction of a particular gene in genome,
promoter is a short region of DNA. Promoters have various types with different functions …
promoter is a short region of DNA. Promoters have various types with different functions …
BioSeq-Analysis: a platform for DNA, RNA and protein sequence analysis based on machine learning approaches
B Liu - Briefings in bioinformatics, 2019 - academic.oup.com
With the avalanche of biological sequences generated in the post-genomic age, one of the
most challenging problems is how to computationally analyze their structures and functions …
most challenging problems is how to computationally analyze their structures and functions …
[HTML][HTML] iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC
Abstract N 6-methyladenine (6mA) is one kind of post-replication modification (PTM or
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will …
iRSpot-EL: identify recombination spots with an ensemble learning approach
B Liu, S Wang, R Long, KC Chou - Bioinformatics, 2017 - academic.oup.com
Motivation Coexisting in a DNA system, meiosis and recombination are two indispensible
aspects for cell reproduction and growth. With the avalanche of genome sequences …
aspects for cell reproduction and growth. With the avalanche of genome sequences …
iRNA-PseColl: identifying the occurrence sites of different RNA modifications by incorporating collective effects of nucleotides into PseKNC
There are many different types of RNA modifications, which are essential for numerous
biological processes. Knowledge about the occurrence sites of RNA modifications in its …
biological processes. Knowledge about the occurrence sites of RNA modifications in its …
[HTML][HTML] MLACP: machine-learning-based prediction of anticancer peptides
Cancer is the second leading cause of death globally, and use of therapeutic peptides to
target and kill cancer cells has received considerable attention in recent years. Identification …
target and kill cancer cells has received considerable attention in recent years. Identification …
2L-piRNA: a two-layer ensemble classifier for identifying piwi-interacting RNAs and their function
B Liu, F Yang, KC Chou - Molecular Therapy-Nucleic Acids, 2017 - cell.com
Involved with important cellular or gene functions and implicated with many kinds of cancers,
piRNAs, or piwi-interacting RNAs, are of small non-coding RNA with around 19–33 nt in …
piRNAs, or piwi-interacting RNAs, are of small non-coding RNA with around 19–33 nt in …