Production of extended-spectrum β-lactamases (ESBLs) is the principal mechanism of
resistance to oxyimino-cephalosporins evolved by members of the family …

Many, if not most, enzymes can promiscuously catalyze reactions, or act on substrates, other
than those for which they evolved. Here, we discuss the structural, mechanistic, and …

β-Lactamase evolution presents to the infectious disease community a major challenge in
the treatment of infections caused by multidrug-resistant gram-negative bacteria. Because …

The most common mechanism of resistance to β-lactam antibiotics in Gram-negative
bacteria is the production of β-lactamases that hydrolyze the drugs. Class A β-lactamases …

Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is
assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of …

Although β-lactams have been the most effective class of antibacterial agents used in
clinical practice for the past half century, their effectiveness on Gram-negative bacteria has …

For medical biologists, sequencing has become a commonplace technique to support
diagnosis. Rapid changes in this field have led to the generation of large amounts of data …

ABSTRACT Introduction: Multi-drug-resistant Klebsiella pneumoniae is currently one of the
most pressing emerging issues in bacterial resistance. Treatment of K. pneumoniae …

Background Avibactam is a novel broad-range β-lactamase inhibitor active against Ambler
class A (including ESBL and KPC) and some Ambler class C and D (eg OXA-48) enzymes …

The use of the three classical β-lactamase inhibitors (clavulanic acid, tazobactam and
sulbactam) in combination with β-lactam antibacterials is currently the most successful …