The “root” causes behind the anti-inflammatory actions of ginger compounds in immune cells

K Pázmándi, AG Szöllősi, T Fekete - Frontiers in Immunology, 2024 - frontiersin.org
Ginger (Zingiber officinale) is one of the most well-known spices and medicinal plants
worldwide that has been used since ancient times to treat a plethora of diseases including …

Macrophage polarization and its impact on idiopathic pulmonary fibrosis

Z Ge, Y Chen, L Ma, F Hu, L **e - Frontiers in Immunology, 2024 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a lung disease that worsens over time, causing fibrosis
in the lungs and ultimately resulting in respiratory failure and a high risk of death …

[HTML][HTML] The crosstalk between DNA-damage responses and innate immunity

M He, H Jiang, S Li, M Xue, H Wang, C Zheng… - International …, 2024 - Elsevier
DNA damage is typically caused during cell growth by DNA replication stress or exposure to
endogenous or external toxins. The accumulation of damaged DNA causes genomic …

[HTML][HTML] TRIM29 controls enteric RNA virus-induced intestinal inflammation by targeting NLRP6 and NLRP9b signaling pathways

J Wang, L Wang, W Lu, N Farhataziz, A Gonzalez… - Mucosal …, 2024 - Elsevier
Infections by enteric virus and intestinal inflammation are recognized as a leading cause of
deadly gastroenteritis, and NLRP6 and NLRP9b signaling control these infection and …

Influenza virus infection activates TAK1 to suppress RIPK3-independent apoptosis and RIPK1-dependent necroptosis

Y Sun, L Ji, W Liu, J Sun, P Liu, X Wang, X Liu… - Cell Communication and …, 2024 - Springer
Many DNA viruses develop various strategies to inhibit cell death to facilitate their
replication. However, whether influenza A virus (IAV), a fast-replicating RNA virus …

Endoplasmic reticulum stress in diseases

Y Liu, C Xu, R Gu, R Han, Z Li, X Xu - MedComm, 2024 - Wiley Online Library
The endoplasmic reticulum (ER) is a key organelle in eukaryotic cells, responsible for a wide
range of vital functions, including the modification, folding, and trafficking of proteins, as well …

Impaired arginine/ornithine metabolism drives severe HFMD by promoting cytokine storm

Y Zhang, Q Yang, Q Peng, Z Tian, F Lv, X Zeng… - Frontiers in …, 2024 - frontiersin.org
Introduction The Hand, Foot and Mouth Disease (HFMD), caused by enterovirus 71
infection, is a global public health emergency. Severe HFMD poses a significant threat to the …

1, 25-D3 ameliorates ischemic brain injury by alleviating endoplasmic reticulum stress and ferroptosis: Involvement of vitamin D receptor and p53 signaling

T Song, J Li, Y **a, S Hou, X Zhang, Y Wang - Cellular Signalling, 2024 - Elsevier
Endoplasmic reticulum stress (ERS) and ferroptosis are linked to cerebral ischemia
reperfusion injury (CIRI). The neuroprotective properties of 1α, 25-dihydroxyvitamin D3 …

Extracellular vesicles from a novel Lactiplantibacillus plantarum strain suppress inflammation and promote M2 macrophage polarization

S Gong, R Zeng, L Liu, R Wang, M Xue… - Frontiers in …, 2024 - frontiersin.org
Background Lactiplantibacillus plantarum (L. plantarum) is known for its probiotic properties,
including antioxidant and anti-inflammatory effects. Recent studies have highlighted the role …

Role of N6-methyladenosine methylation in head and neck cancer and its regulation of innate immune pathways

L Cao, G Huang, J Fan, X Liu, Z Ma - Frontiers in Immunology, 2024 - frontiersin.org
N6-methyladenosine (m6A) is considered the most prevalent methylation modification in
messenger RNA (mRNA) that critically impacts head and neck cancer (HNC) pathogenesis …