The exosome journey: from biogenesis to uptake and intracellular signalling
S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …
testing exosomes for diagnostic and therapeutic applications are generating remarkable …
Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …
Extracellular vesicles in cancer: cell-to-cell mediators of metastasis
Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular
communication between tumor cells and stromal cells in local and distant …
communication between tumor cells and stromal cells in local and distant …
Exosomes in cancer development, metastasis, and immunity
L Zhang, D Yu - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2019 - Elsevier
Exosomes play essential roles in intercellular communications. The exosome was
discovered in 1983, when it was found that reticulocytes release 50-nm small vesicles …
discovered in 1983, when it was found that reticulocytes release 50-nm small vesicles …
Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance
Exosomes are natural nanovesicles excreted by many cells for intercellular communication
and for transfer of materials including proteins, nucleic acids and even synthetic therapeutic …
and for transfer of materials including proteins, nucleic acids and even synthetic therapeutic …
Exosome-based cell-cell communication in the tumor microenvironment
J Maia, S Caja, MC Strano Moraes, N Couto… - Frontiers in cell and …, 2018 - frontiersin.org
Tumors are not isolated entities, but complex systemic networks involving cell-cell
communication between transformed and non-transformed cells. The milieu created by …
communication between transformed and non-transformed cells. The milieu created by …
Exosomes in cancer: small particle, big player
X Zhang, X Yuan, H Shi, L Wu, H Qian, W Xu - Journal of hematology & …, 2015 - Springer
Exosomes have emerged as a novel mode of intercellular communication. Exosomes can
shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs …
shuttle bioactive molecules including proteins, DNA, mRNA, as well as non-coding RNAs …
Effects of immune cells and cytokines on inflammation and immunosuppression in the tumor microenvironment
L Li, R Yu, T Cai, Z Chen, M Lan, T Zou, B Wang… - International …, 2020 - Elsevier
Chronic inflammation and immune responses are two core element that characterize the
tumor microenvironment. A large number of immune/inflammatory cells (including tumor …
tumor microenvironment. A large number of immune/inflammatory cells (including tumor …
The biology of cancer exosomes: insights and new perspectives
CF Ruivo, B Adem, M Silva, SA Melo - Cancer research, 2017 - AACR
Exosomes are a subclass of extracellular vesicles involved in intercellular communication
that are released by all cell types, including cancer cells. Cancer exosomes carry malignant …
that are released by all cell types, including cancer cells. Cancer exosomes carry malignant …