Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer

M Levin - Cell, 2021 - cell.com
How are individual cell behaviors coordinated toward invariant large-scale anatomical
outcomes in development and regeneration despite unpredictable perturbations …

Electrical stimulation system based on electroactive biomaterials for bone tissue engineering

X Zhang, T Wang, Z Zhang, H Liu, L Li, A Wang… - Materials Today, 2023 - Elsevier
Traumatic injuries can lead to large bone defects under extreme conditions, which usually
take a long recovery period, while the prognosis is poor. Endogenous electric field, as one …

Ion channels in cancer: are cancer hallmarks oncochannelopathies?

N Prevarskaya, R Skryma, Y Shuba - Physiological reviews, 2018 - journals.physiology.org
Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

Unraveling the mechanistic effects of electric field stimulation towards directing stem cell fate and function: A tissue engineering perspective

G Thrivikraman, SK Boda, B Basu - Biomaterials, 2018 - Elsevier
Electric field (EF) stimulation can play a vital role in eliciting appropriate stem cell response.
Such an approach is recently being established to guide stem cell differentiation through …

Membrane potential and cancer progression

M Yang, WJ Brackenbury - Frontiers in physiology, 2013 - frontiersin.org
Membrane potential (Vm), the voltage across the plasma membrane, arises because of the
presence of different ion channels/transporters with specific ion selectivity and permeability …

The roles of K+ channels in cancer

LA Pardo, W Stühmer - Nature Reviews Cancer, 2014 - nature.com
Potassium channels are transmembrane proteins that selectively facilitate the flow of
potassium ions down an electrochemical gradient. These molecules have been studied in …

Potassium channels in cell cycle and cell proliferation

D Urrego, AP Tomczak, F Zahed… - … of the Royal …, 2014 - royalsocietypublishing.org
Normal cell-cycle progression is a crucial task for every multicellular organism, as it
determines body size and shape, tissue renewal and senescence, and is also crucial for …

Bioelectric signaling as a unique regulator of development and regeneration

MP Harris - Development, 2021 - journals.biologists.com
It is well known that electrical signals are deeply associated with living entities. Much of our
understanding of excitable tissues is derived from studies of specialized cells of neurons or …

The bioelectric code: An ancient computational medium for dynamic control of growth and form

M Levin, CJ Martyniuk - Biosystems, 2018 - Elsevier
What determines large-scale anatomy? DNA does not directly specify geometrical
arrangements of tissues and organs, and a process of encoding and decoding for …

Interstitial cells of Cajal and human colon motility in health and disease

JD Huizinga, A Hussain… - American Journal of …, 2021 - journals.physiology.org
Our understanding of human colonic motility, and autonomic reflexes that generate motor
patterns, has increased markedly through high-resolution manometry. Details of the motor …