Radicals: reactive intermediates with translational potential
M Yan, JC Lo, JT Edwards… - Journal of the American …, 2016 - ACS Publications
This Perspective illustrates the defining characteristics of free radical chemistry, beginning
with its rich and storied history. Studies from our laboratory are discussed along with recent …
with its rich and storied history. Studies from our laboratory are discussed along with recent …
Chemical proteomics approaches for identifying the cellular targets of natural products
Covering: 2010 up to 2016 Deconvoluting the mode of action of natural products and drugs
remains one of the biggest challenges in chemistry and biology today. Chemical proteomics …
remains one of the biggest challenges in chemistry and biology today. Chemical proteomics …
“Inverse drug discovery” strategy to identify proteins that are targeted by latent electrophiles as exemplified by aryl fluorosulfates
Drug candidates are generally discovered using biochemical screens employing an isolated
target protein or by utilizing cell-based phenotypic assays. Both noncovalent and covalent …
target protein or by utilizing cell-based phenotypic assays. Both noncovalent and covalent …
Development and applications of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) as a bioorthogonal reaction
L Li, Z Zhang - Molecules, 2016 - mdpi.com
The emergence of bioorthogonal reactions has greatly broadened the scope of biomolecule
labeling and detecting. Of all the bioorthogonal reactions that have been developed, the …
labeling and detecting. Of all the bioorthogonal reactions that have been developed, the …
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors
DS Johnson, E Weerapana… - Future medicinal …, 2010 - Taylor & Francis
This article presents several covalent inhibitors, including examples of successful drugs, as
well as highly selective, irreversible inhibitors of emerging therapeutic targets, such as fatty …
well as highly selective, irreversible inhibitors of emerging therapeutic targets, such as fatty …
Covalent protein modification: the current landscape of residue-specific electrophiles
DA Shannon, E Weerapana - Current opinion in chemical biology, 2015 - Elsevier
Highlights•Electrophiles can show distinct amino-acid selectivities in proteomes.•The
judicious selection of an electrophile is critical to various chemical-proteomic applications.•A …
judicious selection of an electrophile is critical to various chemical-proteomic applications.•A …
Electrophilic natural products and their biological targets
Covering: 1900 to 2011 The study of biologically active natural products has resulted in
seminal contributions to our understanding of living systems. In the case of electrophilic …
seminal contributions to our understanding of living systems. In the case of electrophilic …
Biosynthesis and chemical diversity of β-lactone natural products
Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and
pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been …
pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been …
Enzymatic Activity Profiling Using an Ultrasensitive Array of Chemiluminescent Probes for Bacterial Classification and Characterization
Identification and characterization of bacterial species in clinical and industrial settings
necessitate the use of diverse, labor-intensive, and time-consuming protocols as well as the …
necessitate the use of diverse, labor-intensive, and time-consuming protocols as well as the …
Natural products as chemical probes
EE Carlson - ACS chemical biology, 2010 - ACS Publications
Natural products have evolved to encompass a broad spectrum of chemical and functional
diversity. It is this diversity, along with their structural complexity, that enables nature's small …
diversity. It is this diversity, along with their structural complexity, that enables nature's small …