Ever since microRNAs (miRNAs) were first recognized as an extensive gene family> 20
years ago, a broad community of researchers was drawn to investigate the universe of small …

Argonaute proteins are highly conserved in almost all organisms. They not only involve in
the biogenesis of small regulatory RNAs, but also regulate gene expression and defend …

RNA-guided enzymes must quickly search a vast sequence space for their targets. This
search is aided by chaperones such as Hfq, a protein that mediates regulation by bacterial …

Many proteins that bind specific DNA sequences search the genome by combining three-
dimensional diffusion with one-dimensional sliding on nonspecific DNA,,,–. Here we …

It is vital to diagnose pathogens quickly and effectively in the research and treatment of
disease. Argonaute (Ago) proteins are recently discovered nucleases with nucleic acid …

Super-resolution imaging allows for the visualization of cellular structures on a nanoscale
level. DNA-PAINT (DNA point accumulation in nanoscale topology) is a super-resolution …

Cellular differentiation is directly determined by concentration gradients of morphogens. As
a central model for gradient formation during development, Hedgehog (Hh) morphogens …

Argonaute (AGO) proteins associate with guide RNAs to form complexes that slice
transcripts that pair to the guide. This slicing drives post-transcriptional gene silencing …

The accurate reading of genetic information during transcription is essential for the
expression of genes. Sequence binding specificity very often is attributed to short-range …

Patterns of gene expression, cell growth and cell-type specification during development are
often regulated by morphogens. Morphogens are signalling molecules produced by groups …