Mitophagy is an essential mitochondrial quality control mechanism that eliminates damaged
mitochondria and the production of reactive oxygen species (ROS). The relationship …

Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill
patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is …

Acute kidney injury (AKI) is a commonly encountered syndrome associated with various
aetiologies and pathophysiological processes leading to decreased kidney function. In …

Sepsis is a dysregulated immune response to an infection that leads to organ dysfunction.
Knowledge of the pathophysiology of organ failure in sepsis is crucial for optimizing the …

Microvascular endothelial cells in the kidney have been a neglected cell type in sepsis-
induced acute kidney injury (sepsis-AKI) research; yet, they offer tremendous potential as …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity
and mortality. Although advances in medical management have improved the in-hospital …

Sepsis-associated acute kidney injury (S-AKI) is a common, life-threatening complication in
hospitalized and critically ill patients. S-AKI increases in-hospital mortality 6-fold to 8-fold, 1 …

Acute kidney injury (AKI) is a prevalent pathological condition that is characterized by a
precipitous decline in renal function. In recent years, a growing body of studies have …

Background Growing evidence associates organ dysfunction (s) with impaired metabolism
in sepsis. Recent research has increased our understanding of the role of substrate …

Development of organ dysfunction is the most important clinical event during sepsis, as it
directly relates to mortality and morbidity. Although the new definition of sepsis captures this …