Fluorescent small organic probes for biosensing

X Tian, LC Murfin, L Wu, SE Lewis, TD James - Chemical science, 2021 - pubs.rsc.org
Small-molecule based fluorescent probes are increasingly important for the detection and
imaging of biological signaling molecules due to their simplicity, high selectivity and …

Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents

AC Sedgwick, L Wu, HH Han, SD Bull, XP He… - Chemical Society …, 2018 - pubs.rsc.org
In this review we will explore recent advances in the design and application of excited-state
intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based …

Reaction-based fluorescent probes for the detection and imaging of reactive oxygen, nitrogen, and sulfur species

L Wu, AC Sedgwick, X Sun, SD Bull… - Accounts of chemical …, 2019 - ACS Publications
Conspectus This Account describes a range of strategies for the development of fluorescent
probes for detecting reactive oxygen species (ROS), reactive nitrogen species (RNS), and …

Dual-locked spectroscopic probes for sensing and therapy

L Wu, J Huang, K Pu, TD James - Nature Reviews Chemistry, 2021 - nature.com
Optical imaging probes allow us to detect and uncover the physiological and pathological
functions of an analyte of interest at the molecular level in a non-invasive, longitudinal …

Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications

J Zielonka, J Joseph, A Sikora, M Hardy… - Chemical …, 2017 - ACS Publications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Dual-channel fluorescent probe for the simultaneous monitoring of peroxynitrite and adenosine-5′-triphosphate in cellular applications

L Wu, J Liu, X Tian, RR Groleau, B Feng… - Journal of the …, 2021 - ACS Publications
Changes in adenosine triphosphate (ATP) and peroxynitrite (ONOO–) concentrations have
been correlated in a number of diseases including ischemia-reperfusion injury and drug …

Design Principles, Sensing Mechanisms, and Applications of Highly Specific Fluorescent Probes for HOCl/OCl

D Wu, L Chen, Q Xu, X Chen… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Hypochlorous acid/hypochlorite (HOCl/OCl–), one of the most important
reactive oxygen species (ROS), plays vital roles in various physiological and pathological …

Visualization of ONOO and Viscosity in Drug-Induced Hepatotoxicity with Different Fluorescence Signals by a Sensitive Fluorescent Probe

Y Deng, G Feng - Analytical Chemistry, 2020 - ACS Publications
Drug-induced liver injury (DILI) is considered gradually as a serious public health issue, and
hepatotoxicity has been regarded as the main clinical problem caused by it. We suspected …

[HTML][HTML] Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) in plants–maintenance of structural individuality and functional blend

M Mandal, M Sarkar, A Khan, M Biswas, A Masi… - Advances in Redox …, 2022 - Elsevier
The free radicals along with several reactive oxygen species (ROS) and reactive nitrogen
species (RNS) are known to play a dual role in the biological living system which carries a …

ROS/RNS and base dual activatable merocyanine‐based NIR‐II fluorescent molecular probe for in vivo biosensing

X Zhang, Y Chen, H He, S Wang, Z Lei… - Angewandte …, 2021 - Wiley Online Library
Inflammation usually results in high‐level reactive oxygen species (ROS) and reactive
nitrogen species (RNS) not only in acidic tissue but also in alkaline tissue. However …