T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in
secondary lymphoid tissues.'Tfh-like'populations not expressing the canonical Tfh cell …

Plasmodium falciparum malaria still remains a major global public health challenge with
over 220 million new cases and well over 400,000 deaths annually. Most of the deaths occur …

Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver
stages and the disease-causing blood stages of the human malaria parasite Plasmodium …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

A defining feature of successful vaccination is the ability to induce long-lived antigen-specific
memory cells. T follicular helper (Tfh) cells specialize in providing help to B cells in mounting …

With the emergence and success of checkpoint blockade immunotherapy, immuno-oncology
has primarily focused on CD8 T cells, whose cytotoxic programs directly target tumor cells …

Malaria reflects not only a state of immune activation, but also a state of general immune
defect or immunosuppression, of complex etiology that can last longer than the actual …

Humoral immunity is critical for limiting Plasmodium parasite infections and the severity of
malaria. Naturally acquired immunity against malaria occurs inefficiently and protection is …

Malaria infection elicits both protective and pathogenic immune responses, and IL‐27 is a
critical cytokine that regulate effector responses during infection. Here, we identified a critical …

Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …