Innate immune evasion strategies of SARS-CoV-2

JM Minkoff, B tenOever - Nature Reviews Microbiology, 2023 - nature.com
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …

SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”

BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

[HTML][HTML] SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry

J Kee, S Thudium, DM Renner, K Glastad, K Palozola… - Nature, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged at the end of
2019 and caused the devastating global pandemic of coronavirus disease 2019 (COVID …

Enhanced inhibition of MHC-I expression by SARS-CoV-2 Omicron subvariants

M Moriyama, C Lucas, VS Monteiro… - Proceedings of the …, 2023 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs)
possess mutations that confer resistance to neutralizing antibodies within the Spike protein …

SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions

S Vinjamuri, L Li, M Bouvier - Frontiers in immunology, 2022 - frontiersin.org
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. The genome of SARS-
CoV-2 encodes nine accessory proteins that are involved in host-pathogen interaction …

SARS-CoV-2 ORF8: a rapidly evolving immune and viral modulator in COVID-19

A Arduini, F Laprise, C Liang - Viruses, 2023 - mdpi.com
The COVID-19 pandemic has resulted in upwards of 6.8 million deaths over the past three
years, and the frequent emergence of variants continues to strain global health. Although …

SARS-CoV-2 variant spike and accessory gene mutations alter pathogenesis

ME McGrath, Y Xue, C Dillen… - Proceedings of the …, 2022 - National Acad Sciences
The ongoing COVID-19 pandemic is a major public health crisis. Despite the development
and deployment of vaccines against severe acute respiratory syndrome coronavirus 2 …

Does SARS-CoV-2 induce IgG4 synthesis to evade the immune system?

A Rubio-Casillas, EM Redwan, VN Uversky - Biomolecules, 2023 - mdpi.com
SARS-CoV-2, the virus that causes the COVID-19 disease, has been shown to cause
immune suppression in certain individuals. This can manifest as a reduced ability of the …

Positive selection underlies repeated knockout of ORF8 in SARS-CoV-2 evolution

C Wagner, KE Kistler, GA Perchetti, N Baker… - Nature …, 2024 - nature.com
Knockout of the ORF8 protein has repeatedly spread through the global viral population
during SARS-CoV-2 evolution. Here we use both regional and global pathogen sequencing …

SARS-CoV-2 and the host-immune response

DP Maison, Y Deng, M Gerschenson - Frontiers in Immunology, 2023 - frontiersin.org
The SARS-CoV-2 pandemic and the COVID-19 disease have affected everyone globally,
leading to one of recorded history's most significant research surges. As our knowledge …