One of the simplest organic functional groups, the alkyne, offers a broad canvas for the
design of cascade transformations in which up to three new bonds can be added to each of …

Carbo-and heterocycles are widely found in natural products, biologically active structures,
medicinally relevant compounds, and in many other fine chemicals. The development of …

1. INTRODUCTION “Cascade” radical reactions, also known as “tandem” or “domino” radical
reactions, are characterized by the fact that they proceed through two or more consecutive …

According to the CRC dictionary of natural products, 1 90% of chemically individual
molecules discovered in nature contain either a carbocyclic or a heterocyclic subunit. 2 Not …

The Baldwin rules constitute one of the clearest examples of the success which can be
obtained through the application of stereoelectronic concepts to reaction design. With …

Over the past few years, the development of new radical reactions has gained considerable
momentum. Most such radical transformations heavily depend on the in situ generation of …

The broad utility of cyclic structures accounts for the key roles that cycle-forming reactions
play in synthetic designs. Most of these reactions can be classified as either a cyclization of …

Truly important scientific breakthroughs often come from catching the glimpses of order in
chaos and distilling a large body of disjointed data into a clear set of simple concepts. Even …

Conspectus Do not bend the triple bonds! This familiar undergraduate mantra must be
disobeyed if the alkyne group is used as a building block in molecular construction. This …

Dissection of stereoelectronic effects in the transition states (TSs) for noncatalyzed azide–
alkyne cycloadditions suggests two approaches to selective transition state stabilization in …