Aggregation of specific proteins are histopathological hallmarks of several
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …

Abstract Parkinson's disease (PD), the second most common progressive
neurodegenerative disease, develops and progresses for 10–15 years before the clinical …

Background Alpha-synuclein (α-syn) is considered the main pathophysiological protein
component of Lewy bodies in synucleinopathies. α-Syn is an intrinsically disordered protein …

Parkinson's disease (PD) is the second most common neurodegenerative disorder of the
elderly, presenting primarily with symptoms of motor impairment. The disease is diagnosed …

Alzheimer's disease is a progressive, clinically heterogeneous, and particularly complex
neurodegenerative disease characterized by a decline in cognition. Over the last two …

Objective The Systemic Synuclein Sampling Study (S4) measured α-synuclein in multiple
tissues and biofluids within the same patients with Parkinson disease (PD) vs healthy …

Abstract Lewy Body Dementia is the second most frequent neurodegenerative illness
proven to cause dementia, after Alzheimer's disease (AD). It is believed to be vastly …

Parkinson's disease (PD) is a prevalent neurodegenerative disease for which robust
biomarkers are needed. Because protein structure reflects function, we tested whether …

The recent validation of the α-synuclein seed amplification assay as a biomarker with high
sensitivity and specificity for the diagnosis of Parkinson's disease has formed the backbone …

Soluble oligomers of amyloid-forming proteins are implicated as toxic species in the context
of several neurodegenerative diseases. Since the size and shape of these oligomers …