Nasal vaccines: solutions for respiratory infectious diseases

R Nakahashi-Ouchida, K Fujihashi, Y Kurashima… - Trends in Molecular …, 2023 - cell.com
Nasal vaccines induce pathogen-specific dual protective immunity at mucosal surfaces and
systemically throughout the body. Consequently, nasal vaccines both prevent pathogen …

Differences in the anatomy and physiology of the human and rat respiratory tracts and impact on toxicological assessments

AO Stucki, UG Sauer, DG Allen, NC Kleinstreuer… - Regulatory Toxicology …, 2024 - Elsevier
Inhalation is a critical route through which substances can exert adverse effects in humans;
therefore, it is important to characterize the potential effects that inhaled substances may …

RNA-mediated symmetry breaking enables singular olfactory receptor choice

AD Pourmorady, EV Bashkirova, AM Chiariello… - Nature, 2024 - nature.com
Olfactory receptor (OR) choice provides an extreme example of allelic competition for
transcriptional dominance, where every olfactory neuron stably transcribes one of …

[HTML][HTML] ER stress transforms random olfactory receptor choice into axon targeting precision

HJ Shayya, JK Kahiapo, R Duffié, KS Lehmann… - Cell, 2022 - cell.com
Olfactory sensory neurons (OSNs) convert the stochastic choice of one of> 1,000 olfactory
receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in …

The olfactory bulb in companion animals—anatomy, physiology, and clinical importance

R Alvites, A Caine, GB Cherubini, J Prada… - Brain sciences, 2023 - mdpi.com
The Olfactory Bulb is a component of the Olfactory System, in which it plays an essential role
as an interface between the peripheral components and the cerebral cortex responsible for …

Nanoligomers targeting human miRNA for the treatment of severe COVID-19 are safe and nontoxic in mice

CR McCollum, CM Courtney, NJ O'Connor… - ACS biomaterials …, 2022 - ACS Publications
The devastating effects of the coronavirus disease 2019 (COVID-19) pandemic have made
clear a global necessity for antiviral strategies. Most fatalities associated with infection from …

Combined Use of Chitosan and Olfactory Mucosa Mesenchymal Stem/Stromal Cells to Promote Peripheral Nerve Regeneration In Vivo

RD Alvites, MV Branquinho, AC Sousa… - Stem cells …, 2021 - Wiley Online Library
Peripheral nerve injury remains a clinical challenge with severe physiological and functional
consequences. Despite the existence of multiple possible therapeutic approaches, until …

Comparison of the effects of septoplasty and sinus lifting simulation in rats on changes in heart rate variability

SG Dragunova, IV Reshetov, TF Kosyreva… - Doklady Biochemistry …, 2021 - Springer
The effects of septoplasty and sinus lifting simulation in rats on changes in the frequency
domain of heart rate variability were compared. In the early postoperative period, the low …

Functional anatomy of mystacial active sensing in rats

S Haidarliu, G Nelinger, L Gantar… - The Anatomical …, 2024 - Wiley Online Library
Rats' whisking motion and objects' palpation produce tactile signals sensed by
mechanoreceptors at the vibrissal follicles. Rats adjust their whisking patterns to target …

Rat Olfactory Mucosa Mesenchymal Stem/Stromal Cells (OM‐MSCs): A Characterization Study

RD Alvites, MV Branquinho, AR Caseiro… - … journal of cell …, 2020 - Wiley Online Library
Stem/stromal cell‐based therapies are a branch of regenerative medicine and stand as an
attractive option to promote the repair of damaged or dysfunctional tissues and organs …