Evaluation of recent intranasal drug delivery systems to the central nervous system

TP Crowe, WH Hsu - Pharmaceutics, 2022 - mdpi.com
Neurological diseases continue to increase in prevalence worldwide. Combined with the
lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a …

Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway

Y Chen, C Zhang, Y Huang, Y Ma, Q Song… - Advanced drug delivery …, 2024 - Elsevier
Intranasal delivery provides a direct and non-invasive method for drugs to reach the central
nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of …

Targeted drug delivery to the brain via intranasal nanoemulsion: Available proof of concept and existing challenges

B Chatterjee, B Gorain, K Mohananaidu… - International journal of …, 2019 - Elsevier
Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs
into the CNS at a higher rate and extent than other conventional routes. The mechanism of …

Olfactory deposition of inhaled nanoparticles in humans

GJM Garcia, JD Schroeter, JS Kimbell - Inhalation toxicology, 2015 - Taylor & Francis
Context: Inhaled nanoparticles can migrate to the brain via the olfactory bulb, as
demonstrated in experiments in several animal species. This route of exposure may be the …

Characterizing regional drug delivery within the nasal airways

J Chen, WH Finlay, R Vehring… - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction The nose has been receiving increased attention as a route for drug delivery. As
the site of deposition constitutes the first point of contact of the body with the drug …

Strategies to facilitate or block nose-to-brain drug delivery

PP Martins, HDC Smyth, Z Cui - International journal of pharmaceutics, 2019 - Elsevier
Nose-to-brain delivery has gained significant interest over the past several decades. This
has resulted in numerous strategies described to improve the delivery of drugs to the brain …

[HTML][HTML] Effects of mask-wearing on the inhalability and deposition of airborne SARS-CoV-2 aerosols in human upper airway

J **, XA Si, R Nagarajan - Physics of Fluids, 2020 - pubs.aip.org
Even though face masks are well accepted as tools useful in reducing COVID-19
transmissions, their effectiveness in reducing viral loads in the respiratory tract is unclear …

Neurodegenerative disorders management: state-of-art and prospects of nano-biotechnology

R Kumar, KR Aadil, K Mondal, YK Mishra… - Critical reviews in …, 2022 - Taylor & Francis
Neurodegenerative disorders (NDs) are highly prevalent among the aging population. It
affects primarily the central nervous system (CNS) but the effects are also observed in the …

Transdermal drug delivery systems: a focused review of the physical methods of permeation enhancement

RS Vaseem, A D'cruz, S Shetty… - Advanced …, 2023 - pmc.ncbi.nlm.nih.gov
The skin is the body's largest organ and serves as a site of administration for various
medications. Transdermal drug delivery systems have several advantages over traditional …

Recent advances in nanotechnology for Intra-nasal drug delivery and clinical applications

G Rai, P Gauba, S Dang - Journal of Drug Delivery Science and …, 2023 - Elsevier
Nanotechnology has proved its tremendous worth in the field of drug delivery and targeting.
Nano formulations have improved the safety and efficacy of various conventional drugs …