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Evaluation of recent intranasal drug delivery systems to the central nervous system
TP Crowe, WH Hsu - Pharmaceutics, 2022 - mdpi.com
Neurological diseases continue to increase in prevalence worldwide. Combined with the
lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a …
lack of modifiable risk factors or strongly efficacious therapies, these disorders pose a …
Intranasal drug delivery: The interaction between nanoparticles and the nose-to-brain pathway
Y Chen, C Zhang, Y Huang, Y Ma, Q Song… - Advanced drug delivery …, 2024 - Elsevier
Intranasal delivery provides a direct and non-invasive method for drugs to reach the central
nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of …
nervous system. Nanoparticles play a crucial role as carriers in augmenting the efficacy of …
Targeted drug delivery to the brain via intranasal nanoemulsion: Available proof of concept and existing challenges
Intranasal delivery has shown to circumvent blood-brain-barrier (BBB) and deliver the drugs
into the CNS at a higher rate and extent than other conventional routes. The mechanism of …
into the CNS at a higher rate and extent than other conventional routes. The mechanism of …
Olfactory deposition of inhaled nanoparticles in humans
Context: Inhaled nanoparticles can migrate to the brain via the olfactory bulb, as
demonstrated in experiments in several animal species. This route of exposure may be the …
demonstrated in experiments in several animal species. This route of exposure may be the …
Characterizing regional drug delivery within the nasal airways
Introduction The nose has been receiving increased attention as a route for drug delivery. As
the site of deposition constitutes the first point of contact of the body with the drug …
the site of deposition constitutes the first point of contact of the body with the drug …
Strategies to facilitate or block nose-to-brain drug delivery
Nose-to-brain delivery has gained significant interest over the past several decades. This
has resulted in numerous strategies described to improve the delivery of drugs to the brain …
has resulted in numerous strategies described to improve the delivery of drugs to the brain …
[HTML][HTML] Effects of mask-wearing on the inhalability and deposition of airborne SARS-CoV-2 aerosols in human upper airway
Even though face masks are well accepted as tools useful in reducing COVID-19
transmissions, their effectiveness in reducing viral loads in the respiratory tract is unclear …
transmissions, their effectiveness in reducing viral loads in the respiratory tract is unclear …
Neurodegenerative disorders management: state-of-art and prospects of nano-biotechnology
Neurodegenerative disorders (NDs) are highly prevalent among the aging population. It
affects primarily the central nervous system (CNS) but the effects are also observed in the …
affects primarily the central nervous system (CNS) but the effects are also observed in the …
Transdermal drug delivery systems: a focused review of the physical methods of permeation enhancement
RS Vaseem, A D'cruz, S Shetty… - Advanced …, 2023 - pmc.ncbi.nlm.nih.gov
The skin is the body's largest organ and serves as a site of administration for various
medications. Transdermal drug delivery systems have several advantages over traditional …
medications. Transdermal drug delivery systems have several advantages over traditional …
Recent advances in nanotechnology for Intra-nasal drug delivery and clinical applications
Nanotechnology has proved its tremendous worth in the field of drug delivery and targeting.
Nano formulations have improved the safety and efficacy of various conventional drugs …
Nano formulations have improved the safety and efficacy of various conventional drugs …