Multiple sclerosis (MS) is an immune-inflammatory disease that attacks and damages
myelinated axons in the central nervous system (CNS) and causes nontraumatic …

Life expectancy has increased immensely over the past decades, bringing new challenges
to the health systems as advanced age increases the predisposition for many diseases. One …

Neurodegenerative diseases of the central nervous system (CNS) are characterized by
progressive neuronal death and neurological dysfunction, leading to increased disability …

The human leukocyte antigen (HLA) haplotype DRB1* 15: 01 is the major risk factor for
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …

Autoimmune diseases (ADs) are a heterogeneous groups of diseases that occur as a results
of loss of tolerance to self antigens. While the etiopathogeneis remain obscure, different …

Background: Multiple sclerosis (MS) is thought to be caused by T-cell mediated autoimmune
dysfunction. Risk of develo** MS is influenced by environmental and genetic factors …

Background Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous
system (CNS), characterized by neuroinflammation, demyelination, and neurodegeneration …

Human leukocyte antigen (HLA) class I and II loci are essential elements of innate and
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …

Background Biopharmaceutical products (BPs) are widely used to treat autoimmune
diseases, but immunogenicity limits their efficacy for an important proportion of patients. Our …

Background Infectious diseases are causally related to a large array of noncommunicable
diseases (NCDs). Identifying genetic determinants of infections and antibody-mediated …