A review of the traditional uses, pharmacology, and toxicology of areca nut

Z Wang, Z Guo, Y Luo, L Ma, X Hu, F Chen, D Li - Phytomedicine, 2024 - Elsevier
Background Areca nut, the fruit of A. catechu, is an important Chinese herbal medicine and
is the first of China's “four southern medicines”. The main chemical components are …

The controversial roles of areca nut: medicine or toxin?

PF Liu, YF Chang - International Journal of Molecular Sciences, 2023 - mdpi.com
Areca nut (AN) is used for traditional herbal medicine and social activities in several
countries. It was used as early as about AD 25-220 as a remedy. Traditionally, AN was …

[HTML][HTML] Complex molecular mechanism of ammonia-induced apoptosis in chicken peripheral blood lymphocytes: miR-27b-3p, heat shock proteins …

J Zhang, J Cui, Y Wang, X Lin, X Teng… - … and Environmental Safety, 2022 - Elsevier
Ammonia gas, a toxic environmental pollutant, is a vital component of PM2. 5 aerosols, and
can decrease human and animal immunity. Peripheral blood lymphocytes (PBLs) are main …

A toxicological review of alkaloids

N Yang, J Guo, J Zhang, S Gao, Q **ang… - Drug and chemical …, 2024 - Taylor & Francis
Alkaloids are naturally occurring compounds with complex structures found in natural plants.
To further improve the understanding of plant alkaloids, this review focuses on the …

Human adipose-derived stem cells preconditioned with a novel herbal formulation **g Shi attenuate doxorubicin-induced cardiac damage

DJY Hsieh, BCK Tsai, P Barik, MA Shibu… - Aging (Albany …, 2023 - pmc.ncbi.nlm.nih.gov
Pathological cardiac hypertrophy is a considerable contributor to global disease burden.
Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since …

Diosgenin attenuates myocardial cell apoptosis triggered by oxidative stress through estrogen receptor to activate the PI3K/Akt and ERK axes

MYC Chen, BCK Tsai, WW Kuo, CH Kuo… - The American Journal …, 2023 - World Scientific
Cardiovascular diseases in post-menopausal women are on a rise. Oxidative stress is the
main contributing factor to the etiology and pathogenesis of cardiovascular diseases …

Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

Y Sun, J Feng, W Hou, H Qi, Y Liu - Frontiers in Pharmacology, 2024 - frontiersin.org
Areca nut (AN), the fruit or seed of Areca catechu Linn, has many uses, including chewing
and medicinal purposes. It has sparked worries about health due to the presence of …

Angiotensin II prompts heart cell apoptosis via AT1 receptor-augmented phosphatase and tensin homolog and miR-320-3p functions to enhance suppression of the …

SY Lu, WZ Hong, BCK Tsai, YC Chang… - Journal of …, 2022 - journals.lww.com
Background: Hypertension is a severe public health risk factor worldwide. Elevated
angiotensin II (Ang II) produced by the renin–angiotensin–aldosterone system can lead to …

Arecoline induces cardiotoxicity by upregulating and activating cardiac hypertrophy-related pathways in Sprague–Dawley rats

TJ Ho, BCK Tsai, CH Kuo, HN Luk, CH Day… - Chemico-biological …, 2022 - Elsevier
Habitual chewing of the areca nut increases the risk of mortality owing to cardiovascular
disease, but few reports have revealed the cardiotoxicity mechanism of the areca nut …

Curcumin-pretreated adipose-derived stem cells enhance the neuroprotective ability to repair rheumatoid arthritis-induced damage in the rat brain

DT Ju, BCK Tsai, MA Sitorus, WW Kuo… - The American journal …, 2022 - World Scientific
Neurodegenerative diseases have become increasingly prevalent in the aged population.
Rheumatoid arthritis (RA) is an autoimmune disease that causes systemic inflammation …