Two-component systems (TCS) comprising sensor histidine kinases and response regulator
proteins are among the most important players in bacterial and archaeal signal transduction …

Two-component systems reprogramme diverse aspects of microbial physiology in response
to environmental cues. Canonical systems are composed of a transmembrane sensor …

Two-component systems are a dominant form of bacterial signal transduction. The
prototypical two-component system consists of a sensor that responds to a specific input (s) …

Biofilms comprising aggregates of microorganisms or multicellular communities have been a
major issue as they cause resistance against antimicrobial agents and biofouling. To date …

Perceiving environmental and internal information and reacting in adaptive ways are
essential attributes of living organisms. Two-component systems are relevant protein …

Response regulators function as the output components of two-component systems, which
couple the sensing of environmental stimuli to adaptive responses. Response regulators …

With rising antibiotic resistance at alarming rates in S. aureus, a major human pathogen, it is
important to identify targets for new antimicrobial therapies. A number of two-component …

Two-component systems (TCS) are protein machineries that enable cells to respond to input
signals. Histidine kinases (HK) are the sensory component, transferring information toward …

The Rcs phosphorelay is a two-component signal transduction system that is induced by cell
envelope stress. RcsB, the response regulator of this signaling system, is a pleiotropic …

The thermosensor histidine kinase DesK from B acillus subtilis senses changes in
membrane fluidity initiating an adaptive response. Structural changes in DesK have been …