X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

Circular RNAs (circRNAs) are covalently closed, endogenous biomolecules in eukaryotes
with tissue-specific and cell-specific expression patterns, whose biogenesis is regulated by …

After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …

Zygotic genome activation (ZGA) is a critical postfertilization step that promotes totipotency
and allows different cell fates to emerge in the develo** embryo. MERVL (murine …

Motivation Increasing numbers of large scale single cell RNA-Seq projects are leading to a
data explosion, which can only be fully exploited through data integration. A number of …

Large-scale sequencing of RNA from individual cells can reveal patterns of gene, isoform
and allelic expression across cell types and states. However, current short-read single-cell …

Single-cell RNA sequencing (scRNA-seq) technologies allow the dissection of gene
expression at single-cell resolution, which greatly revolutionizes transcriptomic studies. A …

Single-cell RNA sequencing (scRNA-seq) allows researchers to collect large catalogues
detailing the transcriptomes of individual cells. Unsupervised clustering is of central …

Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …

Rapid progress in the development of next-generation sequencing (NGS) technologies in
recent years has provided many valuable insights into complex biological systems, ranging …