Cystic kidneys are common causes of end-stage renal disease, both in children and in
adults. Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive …

The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

Nutrients such as glucose, amino acids and lipids are fundamental sources for the
maintenance of essential cellular processes and homeostasis in all organisms. The nutrient …

Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected
insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory …

Polycystic kidney disease (PKD) is a life-threatening disorder, commonly caused by defects
in polycystin-1 (PC1) or polycystin-2 (PC2), in which tubular epithelia form fluid-filled cysts …

Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder
characterized by bilateral renal cyst formation. Recent identification of signaling cascades …

Depression is one of the most common mental illnesses in modern society. In recent years,
several studies show that there are disturbances in lipid metabolism in depressed patients …

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal,
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …

Mild reduction in food intake was recently shown to slow polycystic kidney disease (PKD)
progression in mouse models, but whether the effect was due to solely reduced calories or …

Recent advances in defining the genetic mechanisms of disease causation and modification
in autosomal dominant polycystic kidney disease (ADPKD) have helped to explain some …