Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies

TV Peres, MRC Schettinger, P Chen… - BMC Pharmacology and …, 2016 - Springer
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …

Manganese-induced neurotoxicity: new insights into the triad of protein misfolding, mitochondrial impairment, and neuroinflammation

DS Harischandra, S Ghaisas, G Zenitsky… - Frontiers in …, 2019 - frontiersin.org
Occupational or environmental exposure to manganese (Mn) can lead to the development of
“Manganism,” a neurological condition showing certain motor symptoms similar to …

Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis

ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …

Manganese in health and disease

DS Avila, RL Puntel, M Aschner - … between essential metal ions and human …, 2013 - Springer
Manganese is an important metal for human health, being absolutely necessary for
development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or …

Organophosphate toxicity: Updates of malathion potential toxic effects in mammals and potential treatments

AM Badr - Environmental science and pollution research, 2020 - Springer
Organophosphorus insecticides toxicity is still considered a major global health problem.
Malathion is one of the most commonly used organophosphates nowadays, as being …

Consequences of disturbing manganese homeostasis

J Baj, W Flieger, A Barbachowska, B Kowalska… - International Journal of …, 2023 - mdpi.com
Manganese (Mn) is an essential trace element with unique functions in the body; it acts as a
cofactor for many enzymes involved in energy metabolism, the endogenous antioxidant …

Redox dynamics of manganese as a mitochondrial life-death switch

MR Smith, J Fernandes, YM Go, DP Jones - Biochemical and biophysical …, 2017 - Elsevier
Abstract Sten Orrenius, MD, Ph. D., pioneered many areas of cellular and molecular
toxicology and made seminal contributions to our knowledge of oxidative stress and …

New insights into manganese toxicity and speciation

B Michalke, K Fernsebner - Journal of Trace Elements in Medicine and …, 2014 - Elsevier
Manganese (Mn) is known to be a neurotoxic agent for nearly 175 years now. A lot of
research has therefore been carried out over the last century. From preliminary describing …

Manganese accumulation in the brain via various transporters and its neurotoxicity mechanisms

I Nyarko-Danquah, E Pajarillo, A Digman, KFA Soliman… - Molecules, 2020 - mdpi.com
Manganese (Mn) is an essential trace element, serving as a cofactor for several key
enzymes, such as glutamine synthetase, arginase, pyruvate decarboxylase, and …

New insights on the role of manganese in Alzheimer's disease and Parkinson's disease

AC Martins Jr, P Morcillo, OM Ijomone… - International journal of …, 2019 - mdpi.com
Manganese (Mn) is an essential trace element that is naturally found in the environment and
is necessary as a cofactor for many enzymes and is important in several physiological …