Cardiac fibroblasts form one of the largest cell populations, in terms of cell numbers, in the
heart. They contribute to structural, biochemical, mechanical and electrical properties of the …

Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

Our understanding of the functions of cardiac fibroblasts has moved beyond their roles in
heart structure and extracellular matrix generation and now includes their contributions to …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in
patients with coronary heart disease. Myocardial ischemia simultaneously induces …

Roughly half of the cells of the heart consist of nonmyocardial cells, with fibroblasts
representing the predominant cell type. It is well established that individual cardiomyocytes …

The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Cardiac function is determined by the dynamic interaction of various cell types and the
extracellular matrix that composes the heart. This interaction varies with the stage of …

Fibroblasts are the predominant cell type in the cardiac interstitium. As the main matrix-
producing cells in the adult mammalian heart, fibroblasts maintain the integrity of the …

Conduction disorders and arrhythmias remain difficult to treat and are increasingly prevalent
owing to the increasing age and body mass of the general population, because both are risk …