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Myasthenia gravis: a comprehensive review of immune dysregulation and etiological mechanisms
Autoimmune myasthenia gravis (MG) is characterized by muscle weakness caused by
antibodies directed against proteins of the neuromuscular junction. The main antigenic …
antibodies directed against proteins of the neuromuscular junction. The main antigenic …
Role of MicroRNAs in Parkinson's disease
Parkinson's disease (PD) is a disabling neurodegenerative disease that manifests with
resting tremor, bradykinesia, rigidity and postural instability. Since the discovery of …
resting tremor, bradykinesia, rigidity and postural instability. Since the discovery of …
DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer
MicroRNAs (miRNAs) are recognized as being central players in many biological processes
and cellular pathways. Their roles in disease have been highlighted first by observation of …
and cellular pathways. Their roles in disease have been highlighted first by observation of …
Regulation of let-7 and its target oncogenes
X Wang, LEI Cao, Y Wang, X Wang… - Oncology …, 2012 - spandidos-publications.com
MicroRNAs (miRNAs) are highly evolutionarily-conserved non-coding small RNAs, which
were first identified in Caenorhabditis elegans. Let-7 miRNA is involved in the regulation of …
were first identified in Caenorhabditis elegans. Let-7 miRNA is involved in the regulation of …
Aberrant regulation of the LIN28A/LIN28B and let-7 loop in human malignant tumors and its effects on the hallmarks of cancer
RNA binding proteins (RBPs) and microRNAs (miRNAs) are two of the most important post-
transcriptional regulators of gene expression, and their aberrant expression contributes to …
transcriptional regulators of gene expression, and their aberrant expression contributes to …
[HTML][HTML] MicroRNA: Small RNA mediators of the brains genomic response to environmental stress
The developmental processes that establish the synaptic architecture of the brain while
retaining capacity for activity-dependent remodeling, are complex and involve a combination …
retaining capacity for activity-dependent remodeling, are complex and involve a combination …
Molecular mechanisms and microRNAs in osteosarcoma pathogenesis
This review summarizes data on microRNA (miRNA) genomic organization, biogenesis, and
functions in carcinogenesis. The roles of key genes and regulatory miRNAs in molecular …
functions in carcinogenesis. The roles of key genes and regulatory miRNAs in molecular …
Let-7 microRNAs regenerate peripheral nerve regeneration by targeting nerve growth factor
Peripheral nerve injury is a common clinical problem. Nerve growth factor (NGF) promotes
peripheral nerve regeneration, but its clinical applications are limited by several constraints …
peripheral nerve regeneration, but its clinical applications are limited by several constraints …
MicroRNA dysregulation in the spinal cord following traumatic injury
Spinal cord injury (SCI) triggers a multitude of pathophysiological events that are tightly
regulated by the expression levels of specific genes. Recent studies suggest that changes in …
regulated by the expression levels of specific genes. Recent studies suggest that changes in …
[HTML][HTML] Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production
Objective FAS-mediated apoptosis of hepatocytes and aberrant TGF-β signaling are major
drivers of liver fibrosis. Decreased miRNA let-7 expression in the livers of patients and …
drivers of liver fibrosis. Decreased miRNA let-7 expression in the livers of patients and …