Antifolate antimalarial drugs interfere with folate metabolism, a pathway essential to malaria
parasite survival. This class of drugs includes effective causal prophylactic and therapeutic …

Chemotherapy remains the most important means of controlling malaria, one of the
deadliest infectious parasitic diseases in the world. Antimalarial antifolates have been …

The field of photopharmacology aims to introduce smart drugs that, through the
incorporation of molecular photoswitches, allow for the remote spatial and temporal control …

Tetrahydrofolate cofactors are essential for the synthesis of purines, certain amino acids,
and thymidine. Most bacteria and plants produce these folate cofactors by de novo …

Although malaria remains a big burden to many countries that it threatens their socio-
economic stability, particularly in the countries where malaria is endemic, there have been …

Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet,
unfortunately, apart from artemisinin combination therapies there are relatively few effective …

Using fragment-based design strategy, new pyridyl-indole hybrids 4a–y and indole
intermediates 3a–e were synthesized using multicomponent one pot reaction. The …

Novel analogues of pyrimethamine (Pyr) and cycloguanil (Cyc) have been synthesized and
tested as inhibitors of Plasmodium falciparum dihydrofolate reductase carrying triple (N51I+ …

The Plasmodium falciparum dihydrofolate reductase (PfDHFR) and dihydroorotate
dehydrogenase (PfDHODH) are essential for Plasmodium falciparum growth and …

The progresses made in the field of drug design to combat tropical protozoan parasitic
diseases, such as Chagas' disease, leishmaniasis, and slee** sickness are discussed …