Many cognitive abilities decline with age even in the absence of detectable pathology.
Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms …

Heritability studies document substantial genetic influences on cognitive performance and
decline in old age. Increasing evidence shows that effects of genetic variations on cognition …

The dedifferentiation theory of aging proposes that a reduction in the specificity of neural
representations causes declines in complex cognition as people get older, and may reflect a …

Background Cognitive dysfunction is common among patients with brain tumors and can be
associated with the disease and treatment with radiotherapy and chemotherapy. However …

Introduction Alzheimer's disease (AD) is the leading cause of dementia, and currently, no
effective treatments are available to reverse or halt its progression in clinical practice …

Parkinson's disease (PD) is an important model for the role of dopamine in supporting
human cognition. However, despite the uniformity of midbrain dopamine depletion only …

The retina has been considered a" window to the brain" and shares similar innervation by
the dopaminergic system with the cortex in terms of an unequal distribution of D1 and D2 …

With ever-increasing elder populations, age-related cognitive decline, which is
characterized as a gradual decline in cognitive capacity in the aging process, has turned out …

Insufficient or excessive dopaminergic tone impairs cognitive performance. We examine
whether the balance between transmitter availability and dopamine (DA) D2 receptors …

Objectives Cognitive dysfunction affects a substantial proportion of patients with bipolar
disorder (BD), and genetic‐imaging paradigms may aid in the elucidation of mechanisms …