Mesenchymal stem cell-derived exosomes: applications in regenerative medicine

MD Hade, CN Suire, Z Suo - Cells, 2021 - mdpi.com
Exosomes are a type of extracellular vesicles, produced within multivesicular bodies, that
are then released into the extracellular space through a merging of the multivesicular body …

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week

SM Davidson, P Ferdinandy, I Andreadou… - Journal of the American …, 2019 - jacc.org
Many treatments have been identified that confer robust cardioprotection in experimental
animal models of acute ischemia and reperfusion injury. However, translation of these …

Treatment of infarcted heart tissue via the capture and local delivery of circulating exosomes through antibody-conjugated magnetic nanoparticles

S Liu, X Chen, L Bao, T Liu, P Yuan, X Yang… - Nature biomedical …, 2020 - nature.com
The systemic biodistribution of endogenous extracellular vesicles is central to the
maintenance of tissue homeostasis. Here, we show that angiogenesis and heart function in …

Native and bioengineered extracellular vesicles for cardiovascular therapeutics

RC de Abreu, H Fernandes… - Nature reviews …, 2020 - nature.com
Extracellular vesicles (EVs) are a heterogeneous group of natural particles that are relevant
to the treatment of cardiovascular diseases. These endogenous vesicles have certain …

Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection

HE Bøtker, D Hausenloy, I Andreadou… - Basic research in …, 2018 - Springer
The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …

Isolation of exosomes from blood plasma: qualitative and quantitative comparison of ultracentrifugation and size exclusion chromatography methods

T Baranyai, K Herczeg, Z Onódi, I Voszka, K Módos… - PloS one, 2015 - journals.plos.org
Background Exosomes are emerging targets for biomedical research. However, suitable
methods for the isolation of blood plasma-derived exosomes without impurities have not yet …

Remote ischemic conditioning

G Heusch, HE Bøtker, K Przyklenk, A Redington… - Journal of the American …, 2015 - jacc.org
In remote ischemic conditioning (RIC), brief, reversible episodes of ischemia with
reperfusion in one vascular bed, tissue, or organ confer a global protective phenotype and …

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European …

JPG Sluijter, SM Davidson, CM Boulanger… - Cardiovascular …, 2018 - academic.oup.com
Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …

Plasma exosomes protect the myocardium from ischemia-reperfusion injury

JM Vicencio, DM Yellon, V Sivaraman, D Das… - Journal of the American …, 2015 - jacc.org
Background: Exosomes are nanometer-sized vesicles released from cells into the blood,
where they can transmit signals throughout the body. Shown to act on the heart, exosomes' …

Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote …

P Ferdinandy, DJ Hausenloy, G Heusch… - Pharmacological …, 2014 - Elsevier
Abstract Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …