Stress and anxiety have intertwined behavioral and neural underpinnings. These
commonalities are critical for understanding each state, as well as their mutual interactions …

There is a growing recognition of the importance of the commensal intestinal microbiota in
the development and later function of the central nervous system. Research using germ-free …

Although anxiety disorders represent a major societal problem demanding new therapeutic
targets, these efforts have languished in the absence of a mechanistic understanding of this …

The validity of widely used rodent behavioural tests of anxiety has been questioned, as they
often fail to produce consistent results across independent replicate studies. In this study, we …

Background Aging is considered to be associated with progressive changes in the brain and
its associated sensory, motor, and cognitive functions. A large number of studies comparing …

Background Accumulating evidence suggests that commensal bacteria consumption has the
potential to have a positive impact on stress‐related psychiatric disorders. However, the …

The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly
implicated in the pathophysiology of anxiety disorders. Here, we show that, dependent on …

Increasing evidence suggests that a brain–gut–microbiome axis exists, which has the
potential to play a major role in modulating behaviour. However, the role of this axis in …

The prefrontal cortex (PFC) is a cortical brain region that regulates various cognitive
functions. One distinctive feature of the PFC is its protracted adolescent maturation, which is …

Bacterial colonisation of the gut plays a major role in postnatal development and maturation
of key systems that have the capacity to influence central nervous system (CNS) …