Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape
changes, particularly during embryonic development and in equivalent processes in adults …

How adhesive interactions between cells generate and maintain animal tissue structure
remains one of the most challenging and long-standing questions in cell and developmental …

Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis. The
dynamic regulation of cadherins in response to various extracellular signals controls cell …

This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …

p120-catenin stabilizes epithelial cadherin (E-cadherin) in SW48 cells, but the mechanism
has not been established. Here, we show that p120 acts at the cell surface to control …

The association of p120 catenin (p120) with the juxtamembrane domain (JMD) of the
cadherin cytoplasmic tail is critical for the surface stability of cadherin-catenin cell-cell …

Abstract E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial
sheets. Through the homophilic association of E-Cadherin molecules expressed on …

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …

Abstract p120 catenin is the best studied member of a subfamily of proteins that associate
with the cadherin juxtamembrane domain to suppress cadherin endocytosis. p120 also …

The mechanisms by which catenins regulate cadherin function are not fully understood, and
the precise function of p120 catenin (p120ctn) has remained particularly elusive. In …