Kinase targets are being pursued in a variety of diseases beyond cancer, including immune
and metabolic as well as viral, parasitic, fungal and bacterial. In particular, there is a …

Sixteen novel N-(3-carboxyl-9-benzyl-β-carboline-1-yl) ethylamino acids (6a–p) were
synthesized as intercalating lead compounds. In the in vitro cytotoxic assay their IC50 values …

NADPH oxidase (NOX2) is responsible for reactive oxygen species (ROS) production in
neutrophils and has been recognized as a key mediator in inflammatory and cardiovascular …

(E)-2-(benzo [d] thiazol-2-yl)-3-heteroarylacrylonitriles are described as a new class of
selective inhibitors of acetylcholinesterase (AChE). The most potent compound in the series …

The in vivo anti-thrombotic activities of amino acid modified tetrahydro-β-carbolines
depended upon the proximity of the side chain of the amino acid residue to the carboline …

The kinase c-Jun N-terminal Kinase 3 (JNK3) plays an important role in neurodegenerative
diseases. JNK3 inhibitors have shown promising results in treating Alzheimer's and …

To discover analgesics for treating chronic pain 17 novel Schiff's bases, N, N′-(Z-allylidene-
1, 3-diyl) bisamino acid methyl esters were prepared from 1, 1, 3, 3,-tetramethoxypropane …

Based on DOCK scores 18 N-(3-benzyloxycarbonylcarboline-1-yl) ethylamino acid
benzylesters (6a–r) were synthesized as anti-tumor agents. Their IC50 values against five …

Predictive quantitative structure–activity relationship analysis was developed for a diverse
series of recently synthesized 1-aryl-tetrahydroisoquinoline analogs with anti-HIV activities …

To increase antithrombotic activity, 3S-tetrahydroisoquinoline-3-carboxylic acid (1) was
modified with natural amino acids to form 19 novel dipeptide analogs, 3S …