Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …

Both interleukin 1 beta (IL-1β) and interleukin-6 (IL-6) are pro-inflammatory cytokines that
play a major role in inflammatory diseases as well as cancer. In this work we investigated …

Simple Summary Signal Transducer and Activator of Transcription 3 (STAT3) is involved in
many normal cellular processes that are tightly regulated. However, aberrant activation of …

Flavonoids are assumed to exert beneficial effects in different types of cancers at high
concentrations. Yet, their molecular mechanisms of action remain unknown. The present …

Phytoestrogen intake is known to be beneficial to decrease breast cancer incidence and
progression. But its molecular mechanisms of action are still unknown. The present study …

Phytoestrogens are known to prevent tumor induction. But their molecular mechanisms of
action are still unknown. This study aimed to examine the effect of apigenin on proliferation …

Epithelial-to-mesenchymal transition (EMT) is a central developmental process implicated in
cancer metastasis. Here we show that the tyrosine kinase PYK2 enhances cell migration …

Drug resistance in chemotherapy is a serious obstacle for the successful treatment of
cancer. Drug resistance is caused by various factors, including the overexpression of P …

Phytoestrogens have been demonstrated to inhibit tumor induction; however, their molecular
mechanisms of action have remained elusive. The present study aimed to investigate the …

Background: This study aimed to examine the effect of apigenin on proliferation and
apoptosis in HER2-overexpressing MDA-MB-453 breast cancer cells. Materials and …