A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene–disease relationships
BACKGROUND Human male infertility has a notable genetic component, including well-
established diagnoses such as Klinefelter syndrome, Y-chromosome microdeletions and …
established diagnoses such as Klinefelter syndrome, Y-chromosome microdeletions and …
Male infertility
A Agarwal, S Baskaran, N Parekh, CL Cho, R Henkel… - The Lancet, 2021 - thelancet.com
It is estimated that infertility affects 8–12% of couples globally, with a male factor being a
primary or contributing cause in approximately 50% of couples. Causes of male subfertility …
primary or contributing cause in approximately 50% of couples. Causes of male subfertility …
Single-cell analysis of develo** and azoospermia human testicles reveals central role of Sertoli cells
LY Zhao, CC Yao, XY **ng, T **g, P Li, ZJ Zhu… - Nature …, 2020 - nature.com
Clinical efficacy of treatments against non-obstructive azoospermia (NOA), which affects 1%
of men, are currently limited by the incomplete understanding of NOA pathogenesis and …
of men, are currently limited by the incomplete understanding of NOA pathogenesis and …
Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia
ZE Kherraf, C Cazin, A Bouker, SFB Mustapha… - The American Journal of …, 2022 - cell.com
Non-obstructive azoospermia (NOA) is a severe and frequent cause of male infertility, often
treated by testicular sperm extraction followed by intracytoplasmic sperm injection. The aim …
treated by testicular sperm extraction followed by intracytoplasmic sperm injection. The aim …
Genetics of male infertility
Approximately 7% of men suffer from fertility problems, the etiology of which are ascribable
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …
to a number of factors acting at pretesticular, posttesticular, or testicular levels. About 20% of …
Genetics of azoospermia
Azoospermia affects 1% of men, and it can be due to:(i) hypothalamic-pituitary
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …
A systematic review and standardized clinical validity assessment of male infertility genes
MS Oud, L Volozonoka, RM Smits… - Human …, 2019 - academic.oup.com
STUDY QUESTION Which genes are confidently linked to human monogenic male
infertility? SUMMARY ANSWER Our systematic literature search and clinical validity …
infertility? SUMMARY ANSWER Our systematic literature search and clinical validity …
Genetic architecture of azoospermia—time to advance the standard of care
MJ Wyrwoll, N Köckerling, M Vockel, AK Dicke, N Rotte… - European urology, 2023 - Elsevier
Background Crypto-and azoospermia (very few/no sperm in the semen) are main
contributors to male factor infertility. Genetic causes for spermatogenic failure (SPGF) …
contributors to male factor infertility. Genetic causes for spermatogenic failure (SPGF) …
Diverse monogenic subforms of human spermatogenic failure
Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically
incurable. Defining the genetic basis of NOA has proven challenging, and the most …
incurable. Defining the genetic basis of NOA has proven challenging, and the most …
Genetic dissection of spermatogenic arrest through exome analysis: clinical implications for the management of azoospermic men
Purpose Azoospermia affects 1% of men and it can be the consequence of spermatogenic
maturation arrest (MA). Although the etiology of MA is likely to be of genetic origin, only 13 …
maturation arrest (MA). Although the etiology of MA is likely to be of genetic origin, only 13 …