It is now 30 years since the first report of a potent zinc-dependent histone deacetylase
(HDAC) inhibitor appeared. Since then, five HDAC inhibitors have received regulatory …

In the current era of genomic medicine, diseases are identified as manifestations of
anomalous patterns of gene expression. Cancer is the principal example among such …

Here we report the development of a proteolysis targeting chimera (PROTAC) based on the
combination of the unique features of the sirtuin rearranging ligands (SirReals) as highly …

Sirtuins are a highly conserved class of NAD+-dependent lysine deacylases. The human
isotype Sirt2 has been implicated in the pathogenesis of cancer, inflammation and …

Dysregulation of both tubulin deacetylases sirtuin 2 (Sirt2) and the histone deacetylase 6
(HDAC6) has been associated with the pathogenesis of cancer and neurodegeneration …

The phenothiazine system was identified as a favorable cap group for potent and selective
histone deacetylase 6 (HDAC6) inhibitors. Here, we report the preparation and systematic …

Suramin is a symmetric polyanionic naphthylurea originally used for the treatment of
trypanosomiasis and onchocerciasis. Suramin and diverse analogues exhibit a broad range …

The structures of melatonin and ferulic acid were merged into tertiary amide-based histone
deacetylase 6 (HDAC6) inhibitors to develop multi-target-directed inhibitors for …

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by a
progressive-fibrosing phenotype. IPF has been associated with aberrant HDAC activities …

Histone deacetylase 6 (HDAC6) catalyzes the removal of an acetyl group from lysine
residues of several non-histone proteins. Here we report the preparation of thiazole …