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New halogen-containing drugs approved by FDA in 2021: An overview on their syntheses and pharmaceutical use
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in
the year 2021) containing at least one halogen atom (covalently bound). The structures …
the year 2021) containing at least one halogen atom (covalently bound). The structures …
Organometallic and coordination rhenium compounds and their potential in cancer therapy
This review focuses on cytotoxic rhenium compounds in terms of IC 50 values, their mode of
action in biological systems and their status in clinical trials. Biological studies of different …
action in biological systems and their status in clinical trials. Biological studies of different …
Preclinical evaluation of a tailor-made DOTA-conjugated PSMA inhibitor with optimized linker moiety for imaging and endoradiotherapy of prostate cancer
M Benešová, M Schäfer, U Bauder-Wüst… - Journal of Nuclear …, 2015 - jnm.snmjournals.org
Despite many advances in the past years, the treatment of metastatic prostate cancer still
remains challenging. In recent years, prostate-specific membrane antigen (PSMA) inhibitors …
remains challenging. In recent years, prostate-specific membrane antigen (PSMA) inhibitors …
Comparison of PET imaging with a 68Ga-labelled PSMA ligand and 18F-choline-based PET/CT for the diagnosis of recurrent prostate cancer
A Afshar-Oromieh, CM Zechmann, A Malcher… - European journal of …, 2014 - Springer
Purpose Positron emission tomography (PET) with choline tracers has found widespread
use for the diagnosis of prostate cancer (PC). However, choline metabolism is not increased …
use for the diagnosis of prostate cancer (PC). However, choline metabolism is not increased …
PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions
A Afshar-Oromieh, A Malcher, M Eder… - European journal of …, 2013 - Springer
Purpose Prostate-specific membrane antigen (PSMA) is a cell surface protein with high
expression in prostate carcinoma (PC) cells. Recently, procedures have been developed to …
expression in prostate carcinoma (PC) cells. Recently, procedures have been developed to …
Novel Preclinical and Radiopharmaceutical Aspects of [68Ga]Ga-PSMA-HBED-CC: A New PET Tracer for Imaging of Prostate Cancer
M Eder, O Neels, M Müller, U Bauder-Wüst, Y Remde… - Pharmaceuticals, 2014 - mdpi.com
The detection of prostate cancer lesions by PET imaging of the prostate-specific membrane
antigen (PSMA) has gained highest clinical impact during the last years. 68Ga-labelled Glu …
antigen (PSMA) has gained highest clinical impact during the last years. 68Ga-labelled Glu …
The smart targeting of nanoparticles
AD Friedman, SE Claypool… - Current pharmaceutical …, 2013 - ingentaconnect.com
One major challenge in nanomedicine is the selective delivery of nanoparticles to diseased
tissues. Nanoparticle delivery systems require targeting for specific delivery to pathogenic …
tissues. Nanoparticle delivery systems require targeting for specific delivery to pathogenic …
2-(3-{1-Carboxy-5-[(6-[18F]Fluoro-Pyridine-3-Carbonyl)-Amino]-Pentyl}-Ureido)-Pentanedioic Acid, [18F]DCFPyL, a PSMA-Based PET Imaging Agent for Prostate …
Purpose: We have synthesized and evaluated in vivo 2-(3-{1-carboxy-5-[(6-[18F] fluoro-
pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid,[18F] DCFPyL, as a potential …
pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid,[18F] DCFPyL, as a potential …
A bright future for precision medicine: advances in fluorescent chemical probe design and their clinical application
The Precision Medicine Initiative aims to use advances in basic and clinical research to
develop therapeutics that selectively target and kill cancer cells. Under the same doctrine of …
develop therapeutics that selectively target and kill cancer cells. Under the same doctrine of …
Aptamer‐functionalized quantum dots as theranostic nanotools against cancer and bacterial infections: a comprehensive overview of recent trends
F Davodabadi, S Mirinejad… - Biotechnology …, 2023 - Wiley Online Library
Aptamers (Apts) are synthetic nucleic acid ligands that can be engineered to target various
molecules, including amino acids, proteins, and pharmaceuticals. Through a series of …
molecules, including amino acids, proteins, and pharmaceuticals. Through a series of …