Tyrosine‐rich peptides as a platform for assembly and material synthesis
The self‐assembly of biomolecules can provide a new approach for the design of functional
systems with a diverse range of hierarchical nanoarchitectures and atomically defined …
systems with a diverse range of hierarchical nanoarchitectures and atomically defined …
Metabolite assemblies: A surprising extension to the amyloid hypothesis
The realization of the ability of metabolites to form self-assembled amyloid-like
nanostructures was a surprising phenomenon. This discovery paved the way towards …
nanostructures was a surprising phenomenon. This discovery paved the way towards …
Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational …
AS Abdul Manap, AC Wei Tan, WH Leong… - Frontiers in aging …, 2019 - frontiersin.org
Hallmarks of Alzheimer's disease (AD) pathology include acetylcholine (ACh) deficiency and
plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact …
plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact …
Unusual aggregates formed by the self-assembly of proline, hydroxyproline, and lysine
There is a plethora of significant research that illustrates toxic self-assemblies formed by the
aggregation of single amino acids, such as phenylalanine, tyrosine, tryptophan, cysteine …
aggregation of single amino acids, such as phenylalanine, tyrosine, tryptophan, cysteine …
Tryptophan self-assembly yields cytotoxic nanofibers containing amyloid-mimicking and cross-seeding competent conformers
Dietary consumption of Trp via protein-based foods is essential for the maintenance of
crucial metabolic processes including the synthesis of proteins and several vital metabolites …
crucial metabolic processes including the synthesis of proteins and several vital metabolites …
Amyloid cross-seeding raises new dimensions to understanding of amyloidogenesis mechanism
Hallmarks of most of the amyloid pathologies are surprisingly found to be heterocomponent
entities such as inclusions and plaques which contain diverse essential proteins and …
entities such as inclusions and plaques which contain diverse essential proteins and …
[HTML][HTML] Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity
Evidence suggests that increased level/aggregation of beta-amyloid (Aβ) peptides initiate
neurodegeneration and subsequent development of Alzheimer's disease (AD). At present …
neurodegeneration and subsequent development of Alzheimer's disease (AD). At present …
A robust yet simple method to generate fluorescent amyloid nanofibers
Covalent tagging of fluorophores is central to the mechanistic understanding of important
biological processes including protein–protein interaction and protein aggregation. Hence …
biological processes including protein–protein interaction and protein aggregation. Hence …
Controlling synthetic membraneless organelles by a red-light-dependent singlet oxygen-generating protein
Membraneless organelles (MLOs) formed via protein phase separation have great
implications for both physiological and pathological processes. However, the inability to …
implications for both physiological and pathological processes. However, the inability to …
Amyloid-mimicking toxic nanofibers generated via self-assembly of dopamine
Molecular self-assembly of biologically relevant aromatic metabolites is known to generate
cytotoxic nanostructures and this unique property has opened up new concepts in the …
cytotoxic nanostructures and this unique property has opened up new concepts in the …