Innate immunity: the first line of defense against SARS-CoV-2

MS Diamond, TD Kanneganti - Nature immunology, 2022 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …

Human genetic and immunological determinants of critical COVID-19 pneumonia

Q Zhang, P Bastard, A Cobat, JL Casanova - Nature, 2022 - nature.com
SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …

Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

The interferon landscape along the respiratory tract impacts the severity of COVID-19

B Sposito, A Broggi, L Pandolfi, S Crotta, N Clementi… - Cell, 2021 - cell.com
Summary Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction
of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) …

Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics

NR Cheemarla, TA Watkins, VT Mihaylova… - Journal of Experimental …, 2021 - rupress.org
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish
infection, and the replication level correlates with the likelihood of viral transmission. Here …

Critical determinants of cytokine storm and type I interferon response in COVID-19 pathogenesis

S Ramasamy, S Subbian - Clinical microbiology reviews, 2021 - journals.asm.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus
disease 2019 (COVID-19), a rapidly evolving pandemic worldwide with at least 68 million …

SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13

CB Morrison, CE Edwards, KM Shaffer… - Proceedings of the …, 2022 - pnas.org
Muco-obstructive lung diseases are typically associated with high risks of COVID-19
severity; however, allergic asthma showed reduced susceptibility. To investigate viral …

Pathogenesis of respiratory viral and fungal coinfections

F Salazar, E Bignell, GD Brown, PC Cook… - Clinical Microbiology …, 2022 - journals.asm.org
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for develo** invasive fungal infections. Influenza virus is one of the most …

Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

J Loske, J Röhmel, S Lukassen, S Stricker… - Nature …, 2022 - nature.com
Children have reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection rates and a substantially lower risk for develo** severe coronavirus disease …

Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies

MM Zhao, Y Zhu, L Zhang, G Zhong, L Tai, S Liu, G Yin… - Cell discovery, 2022 - nature.com
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
an important target for vaccine and drug development. However, the rapid emergence of …