Actin dynamics in cell migration
Cell migration is an essential process, both in unicellular organisms such as amoeba and as
individual or collective motility in highly developed multicellular organisms like mammals. It …
individual or collective motility in highly developed multicellular organisms like mammals. It …
Nucleating actin for invasion
A Nürnberg, T Kitzing, R Grosse - Nature Reviews Cancer, 2011 - nature.com
The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in
metastasis, which is the leading cause of death from cancer. Invasive cell migration requires …
metastasis, which is the leading cause of death from cancer. Invasive cell migration requires …
A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors
Key cellular decisions, such as proliferation or growth arrest, typically occur at spatially
defined locations within tissues. Loss of this spatial control is a hallmark of many diseases …
defined locations within tissues. Loss of this spatial control is a hallmark of many diseases …
Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER
W Heusermann, J Hean, D Trojer, E Steib… - Journal of Cell …, 2016 - rupress.org
Exosomes are nanovesicles released by virtually all cells, which act as intercellular
messengers by transfer of protein, lipid, and RNA cargo. Their quantitative efficiency, routes …
messengers by transfer of protein, lipid, and RNA cargo. Their quantitative efficiency, routes …
Cellular chirality arising from the self-organization of the actin cytoskeleton
Cellular mechanisms underlying the development of left–right asymmetry in tissues and
embryos remain obscure. Here, the development of a chiral pattern of actomyosin was …
embryos remain obscure. Here, the development of a chiral pattern of actomyosin was …
Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change
Summary Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that
nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to …
nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to …
Generation of stress fibers through myosin-driven reorganization of the actin cortex
Contractile actomyosin bundles, stress fibers, govern key cellular processes including
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
Tension is required but not sufficient for focal adhesion maturation without a stress fiber template
Focal adhesion composition and size are modulated in a myosin II–dependent maturation
process that controls adhesion, migration, and matrix remodeling. As myosin II activity drives …
process that controls adhesion, migration, and matrix remodeling. As myosin II activity drives …
Presynapses contain distinct actin nanostructures
D Bingham, CE Jakobs, F Wernert… - Journal of Cell …, 2023 - rupress.org
The architecture of the actin cytoskeleton that concentrates at presynapses remains poorly
known, hindering our understanding of its roles in synaptic physiology. In this work, we …
known, hindering our understanding of its roles in synaptic physiology. In this work, we …
[HTML][HTML] Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and-independent pathways
Cells contain multiple F-actin assembly pathways, including the Arp2/3 complex, formins,
and Ena/VASP, which have largely been analyzed separately. They collectively generate …
and Ena/VASP, which have largely been analyzed separately. They collectively generate …