Polymeric nanoparticles for drug delivery

MA Beach, U Nayanathara, Y Gao, C Zhang… - Chemical …, 2024‏ - ACS Publications
The recent emergence of nanomedicine has revolutionized the therapeutic landscape and
necessitated the creation of more sophisticated drug delivery systems. Polymeric …

Ionotropic gelation of chitosan flat structures and potential applications

P Sacco, S Pedroso-Santana, Y Kumar, N Joly… - Molecules, 2021‏ - mdpi.com
The capability of some polymers, such as chitosan, to form low cost gels under mild
conditions is of great application interest. Ionotropic gelation of chitosan has been used …

Hyaluronic acid coated chitosan nanoparticles reduced the immunogenicity of the formed protein corona

A Almalik, H Benabdelkamel, A Masood, IO Alanazi… - Scientific reports, 2017‏ - nature.com
Studying the interactions of nanoparticles (NPs) with serum proteins is necessary for the
rational development of nanocarriers. Optimum surface chemistry is a key consideration to …

[HTML][HTML] Concepts for develo** physical gels of chitosan and of chitosan derivatives

P Sacco, F Furlani, G De Marzo, E Marsich, S Paoletti… - Gels, 2018‏ - mdpi.com
Chitosan macro-and micro/nano-gels have gained increasing attention in recent years,
especially in the biomedical field, given the well-documented low toxicity, degradability, and …

The CD44‐mediated uptake of hyaluronic acid‐based carriers in macrophages

JM Rios De la Rosa, A Tirella, A Gennari… - Advanced …, 2017‏ - Wiley Online Library
CD44 is a potentially rewarding target in cancer therapy, although its mechanisms of ligand
binding and internalization are still poorly understood. In this study, we have established …

Evaluating the efficiency of hyaluronic acid for tumor targeting via CD44

A Spadea, JM Rios de la Rosa, A Tirella… - Molecular …, 2019‏ - ACS Publications
The development of delivery systems capable of tumor targeting represents a promising
strategy to overcome issues related to nonspecific effects of conventional anticancer …

Chitosan nanoparticles prepared by ionotropic gelation: An overview of recent advances

KG Desai - Critical Reviews™ in Therapeutic Drug Carrier …, 2016‏ - dl.begellhouse.com
The objective of this review is to summarize recent advances in chitosan nanoparticles
prepared by ionotropic gelation. Significant progress has occurred in this area since the …

Combination of hyaluronic acid conjugates with immunogenic cell death inducer and CpG for glioblastoma local chemo-immunotherapy elicits an immune response …

G Catania, G Rodella, K Vanvarenberg, V Préat… - Biomaterials, 2023‏ - Elsevier
The efficacy of standard glioblastoma (GBM) treatments has been limited due to the highly
immunosuppressive tumor immune microenvironment, interpatient tumor heterogenicity and …

Chitosan/hyaluronic acid nanoparticles: rational design revisited for RNA delivery

E Lallana, JM Rios de la Rosa, A Tirella… - Molecular …, 2017‏ - ACS Publications
Chitosan/hyaluronic acid (HA) nanoparticles can be used to deliver an RNA/DNA cargo to
cells overexpressing HA receptors such as CD44. For these systems, unequivocal links …

Targeted modulation of intestinal epithelial regeneration and immune response in ulcerative colitis using dual-targeting bilirubin nanoparticles

Z Zhuo, K Guo, Y Luo, Q Yang, H Wu, R Zeng… - …, 2024‏ - pmc.ncbi.nlm.nih.gov
Rationale: The therapeutic benefits of bilirubin in the treatment of ulcerative colitis (UC) are
considerable, whereas the underlying mechanism of bilirubin on UC remains unclear …