Integration of substrate-and flow-derived stresses in endothelial cell mechanobiology

CA Dessalles, C Leclech, A Castagnino… - Communications …, 2021 - nature.com
Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

Surface engineering of cardiovascular devices for improved hemocompatibility and rapid endothelialization

J Zhao, Y Feng - Advanced Healthcare Materials, 2020 - Wiley Online Library
Cardiovascular devices have been widely applied in the clinical treatment of cardiovascular
diseases. However, poor hemocompatibility and slow endothelialization on their surface still …

Improved cellular infiltration in electrospun fiber via engineered porosity

J Nam, Y Huang, S Agarwal, J Lannutti - Tissue engineering, 2007 - liebertpub.com
Small pore sizes inherent to electrospun matrices can hinder efficient cellular ingrowth. To
facilitate infiltration while retaining its extracellular matrix-like character, electrospinning was …

Cell‐perceived substrate curvature dynamically coordinates the direction, speed, and persistence of stromal cell migration

M Werner, A Petersen, NA Kurniawan… - Advanced …, 2019 - Wiley Online Library
Adherent cells residing within tissues or biomaterials are presented with 3D geometrical
cues from their environment, often in the form of local surface curvatures. While there is …

Construction of a bilayered vascular graft with smooth internal surface for improved hemocompatibility and endothelial cell monolayer formation

X Dong, X Yuan, L Wang, J Liu, AC Midgley, Z Wang… - Biomaterials, 2018 - Elsevier
Formation of a continuous endothelial cell (EC) monolayer inside the luminal surface with
enhanced hemocompatibility, is a promising solution for improving performance and overall …

Mesoscale substrate curvature overrules nanoscale contact guidance to direct bone marrow stromal cell migration

M Werner, NA Kurniawan, G Korus… - Journal of The …, 2018 - royalsocietypublishing.org
The intrinsic architecture of biological tissues and of implanted biomaterials provides cells
with large-scale geometrical cues. To understand how cells are able to sense and respond …

Plasma-based nanostructuring of polymers: A review

LT Phan, SM Yoon, MW Moon - Polymers, 2017 - mdpi.com
There are various fabrication methods for synthesizing nanostructures, among which plasma-
based technology is strongly competitive in terms of its flexibility and friendly uses, economy …

Protein micropatterning in 2.5 D: an approach to investigate cellular responses in multi-cue environments

C van Der Putten, ABC Buskermolen… - … applied materials & …, 2021 - ACS Publications
The extracellular microenvironment is an important regulator of cell functions. Numerous
structural cues present in the cellular microenvironment, such as ligand distribution and …

[HTML][HTML] Aligned fibrous scaffolds promote directional migration of breast cancer cells via caveolin-1/YAP-mediated mechanosensing

P Li, H Zhou, R Yan, W Yan, L Yang, T Li, X Qin… - Materials Today Bio, 2024 - Elsevier
Tumorigenesis and metastasis are highly dependent on the interactions between the tumor
and the surrounding microenvironment. In 3D matrix, the fibrous structure of the extracellular …

Substrate curvature restricts spreading and induces differentiation of human mesenchymal stem cells

SJ Lee, S Yang - Biotechnology journal, 2017 - Wiley Online Library
While cells attach, spread, migrate, proliferate, and differentiate in three‐dimensional (3D)
micromechanical environments, the mechanical factors of these environments influence the …