BACKGROUND Obesity is caused by an imbalance between energy intake, ie eating and
energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide …

Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …

In the face of starvation, animals will engage in high-risk behaviors that would normally be
considered maladaptive. Starving rodents, for example, will forage in areas that are more …

Brown and beige adipocytes arise from distinct developmental origins. Brown adipose tissue
(BAT) develops embryonically from precursors that also give to skeletal muscle. Beige fat …

Obesity and aging are two important epidemic factors for metabolic syndrome and many
other health issues, which contribute to devastating diseases such as cardiovascular …

Estradiol, either from peripheral or central origin, activates multiple molecular
neuroprotective and neuroreparative responses that, being mediated by estrogen receptors …

Systemic insulin sensitivity shows a diurnal rhythm with a peak upon waking,. The molecular
mechanism that underlies this temporal pattern is unclear. Here we show that the nuclear …

Obesity and its' associated metabolic diseases such as type 2 diabetes and cardiometabolic
disorders are significant health problems confronting many countries. A major driver for …

Background Estrogenic actions in the brain prevent obesity. Better understanding of the
underlying mechanisms may facilitate development of new obesity therapies. Scope of …

Oxysterols are metabolites of cholesterol that regulate cholesterol homeostasis. Among
these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross the …